INT172919

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Context Info
Confidence 0.20
First Reported 2003
Last Reported 2003
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.98
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Iapp) extracellular region (Iapp)
Anatomy Link Frequency
pancreatic islets 2
Iapp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 2 95.04 Very High Very High Very High
Somatostatin 2 92.76 High High
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 140 100.00 Very High Very High Very High
Cancer 32 95.72 Very High Very High Very High
Impaired Glucose Tolerance 12 95.04 Very High Very High Very High
Insulin Resistance 14 69.04 Quite High
Diabetes Mellitus 72 66.32 Quite High
Alzheimer's Dementia 4 45.92 Quite Low
Congenital Anomalies 2 40.92 Quite Low
Death 6 37.84 Quite Low
Disease 8 5.00 Very Low Very Low Very Low
Hyperinsulinism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the increased IAPP release seen in pancreatic cancer patients may be responsible, at least in part, for the islet dysfunction seen in these individuals.
Spec (may) Regulation (responsible) of Localization (release) of IAPP associated with pancreatic cancer
1) Confidence 0.20 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 1.13 Pain Relevance 0.09
However, exposure of isolated rat pancreatic islets to hamster pancreatic cancer cells did not change the secretion of insulin and IAPP [17].
Neg (not) Regulation (change) of Localization (secretion) of IAPP in pancreatic islets associated with pancreatic cancer
2) Confidence 0.17 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 0.85 Pain Relevance 0.09

General Comments

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