INT172953

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 33
Total Number 38
Disease Relevance 20.76
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
neck 1
brain 1
epithelial cells 1
nucleus 1
head 1
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Immobilon 1 94.12 High High
Chronic pancreatitis 9 91.40 High High
cytokine 151 90.28 High High
imagery 21 85.76 High High
Inflammation 510 85.64 High High
metalloproteinase 22 84.96 Quite High
Osteoarthritis 16 84.20 Quite High
Central nervous system 16 77.80 Quite High
ischemia 17 76.60 Quite High
rheumatoid arthritis 9 61.12 Quite High
Disease Link Frequency Relevance Heat
Shock 6 100.00 Very High Very High Very High
Apoptosis 592 99.90 Very High Very High Very High
Cancer 1086 99.68 Very High Very High Very High
Brain Tumor 197 99.42 Very High Very High Very High
Breast Cancer 51 99.40 Very High Very High Very High
Adenocarcinoma 67 99.12 Very High Very High Very High
Sarcoma 18 99.12 Very High Very High Very High
Pancreatic Cancer 119 98.92 Very High Very High Very High
Disease 126 98.40 Very High Very High Very High
Cytomegalovirus Infection 4 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothesis that a normal neural stem or progenitor cell can evolve to become a brain tumor stem cell perhaps through a mutation in p53 is a very reasonable one and has got substantial experimental support [27, 29, 31, 94].
p53 Binding (mutation) of in stem associated with brain tumor
1) Confidence 0.37 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.66 Pain Relevance 0.08
What function of p53 is the most important one to inactivate for brain tumor initiation and progression?
p53 Binding (function) of in brain associated with brain tumor
2) Confidence 0.37 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.24 Pain Relevance 0
The p53 plasmid has 13 copies of the p53-binding consensus sequence.
p53 Binding (binding) of
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.10 Pain Relevance 0
The p53 plasmid has 13 copies of the p53-binding consensus sequence.
p53 Binding (binding) of
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.10 Pain Relevance 0
Association of cox-2 and p53 was reported in the studies previously performed.
p53 Binding (Association) of
5) Confidence 0.33 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.61 Pain Relevance 0.03
Recently, by the help of high-throughput genome and transcriptome analyses, human secondary GBs were shown to be similar to the proneural type of primary GBs and associated with PDGFRA amplification, TP53 and PTEN deletion/mutation, IDH1 mutation and also disturbances in the PI3K signaling pathway, and finally by the expression of oligodendrocyte markers [133].
TP53 Binding (associated) of in oligodendrocyte
6) Confidence 0.33 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.71 Pain Relevance 0
Interestingly, Hr also binds HDAC1[11], [37], [38] and possibly might also recruit a complex with p53 resulting in decreased stability through deacetylation.
p53 Spec (might) Binding (complex) of
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.53 Pain Relevance 0
For all tumors, positive TP and p53 staining was associated with an advanced stage compared to tumors with negative staining (p = 0.027 and p = 0.009, respectively).
p53 Binding (associated) of associated with cancer
8) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.23 Pain Relevance 0
Membranes were sequentially blocked in 5% dry milk for 1 hour at RT and then incubated with anti-p53, P21 and P16 antibodies at 1?
p53 Binding (antibodies) of
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.10 Pain Relevance 0.05
Meanwhile, correlation studies with clinico-pathological variables revealed a significant association between positive TP and p53 staining with an advanced stage of the disease.
p53 Binding (association) of associated with disease
10) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.01 Pain Relevance 0
There are also studies available investigating the cox-2 and p53 expressions in ovarian adenocarcinoma and in head and neck tumors and a positive association between cox-2 and p53 was reported [17,20].
p53 Binding (association) of in neck associated with adenocarcinoma and cancer
11) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.35 Pain Relevance 0.05
However, the association between the high levels of the p53 protein and p53 mutations could not be determined in some of the studies [4].
p53 Binding (association) of
12) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.72 Pain Relevance 0
In our study, the association between p53 and cox-2 is also investigated, but no statistically significant evidence was found (p = 0.663).
p53 Binding (association) of
13) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.32 Pain Relevance 0.04
However, considering both cox-2 and p53, significant association of cox-2 and p53 with age, stage and survival were not detected.
p53 Binding (association) of
14) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.22 Pain Relevance 0.03
However, Ohsawa et al. did not determine an association between cox-2 and p53 expression [7].
p53 Neg (not) Binding (association) of
15) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.33 Pain Relevance 0.04
The association between cox-2 expression and p53 is evaluated, but no statistically significant relationship was detected (p > 0.05) (table 4).


p53 Binding (association) of
16) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.17 Pain Relevance 0
The recent generation of mice harboring these signature genetic mutations has yielded models that closely recapitulate the histopathogenesis of the human disease with KrasG12D initiating focal PanINs that rapidly undergo multistage progression in conjunction with Ink4a/Arf or p53 mutations, resulting in invasive PDAC.
p53 Binding (conjunction) of associated with adenocarcinoma and disease
17) Confidence 0.18 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.37 Pain Relevance 0
Furthermore, it has been shown that Smyd2 acts on non-histone targets by inhibiting the functional activity of p53 via methylation of p53, lysine 370 [33].
p53 Binding (methylation) of
18) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.29 Pain Relevance 0
The product of MDM2 interacts with the p53 protein and inhibits its ability to regulate genetic expression as a transcription factor.
p53 Binding (interacts) of
19) Confidence 0.13 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 1.11 Pain Relevance 0
A putative mechanism accounting for the reduced tumorigenic effect was prevention of apoptosis by c-Jun, and the prevention of apoptosis was associated with p53 [68].
p53 Binding (associated) of associated with apoptosis
20) Confidence 0.10 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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