INT172960

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.88
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) nucleus (Smad4) intracellular (Smad4)
DNA binding (Smad4) protein complex (Smad4) cytoplasm (Smad4)
Anatomy Link Frequency
epithelial cells 12
Smad4 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 25 61.92 Quite High
Nerve growth factor 18 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 66 99.68 Very High Very High Very High
Pancreatic Cancer 342 95.08 Very High Very High Very High
Cancer 301 94.48 High High
Colon Cancer 12 65.80 Quite High
Pancreatitis 27 61.92 Quite High
Retinoblastoma 6 47.48 Quite Low
Apoptosis 18 35.60 Quite Low
Microsatellite Instability 6 21.36 Low Low
Stomach Cancer 7 16.16 Low Low
Hyperplasia 6 11.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (loss) of Gene_expression (expression) of DPC4 in epithelial cells
1) Confidence 0.39 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
To confirm the validity of our study, we showed similar frequencies of loss of PTEN and SMAD4 expression in our PDAC samples [24,25], and higher levels of ADAM9 and ?
Negative_regulation (loss) of Gene_expression (expression) of SMAD4 associated with adenocarcinoma
2) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.88 Pain Relevance 0
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (loss) of Gene_expression (expression) of DPC4 in epithelial cells
3) Confidence 0.28 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (loss) of Gene_expression (expression) of Smad4 in epithelial cells
4) Confidence 0.28 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.84 Pain Relevance 0.12
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (inhibition) of Gene_expression (expression) of Smad4 in epithelial cells
5) Confidence 0.28 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (inhibition) of Gene_expression (expression) of DPC4 in epithelial cells
6) Confidence 0.28 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (loss) of Gene_expression (expression) of Smad4 in epithelial cells
7) Confidence 0.28 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox