INT172961

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 16.74
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
fibroblasts 2
HGF 2
salivary gland 2
chief cell 1
epithelium 1
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 124 100.00 Very High Very High Very High
rheumatoid arthritis 100 99.26 Very High Very High Very High
monoamine 13 93.64 High High
cerebral cortex 31 90.64 High High
Arthritis 64 89.56 High High
imagery 44 81.84 Quite High
Inflammation 100 81.36 Quite High
qutenza 12 70.28 Quite High
aspirin 6 66.88 Quite High
Calcitonin gene-related peptide 12 62.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 1066 99.76 Very High Very High Very High
Ulcers 36 99.64 Very High Very High Very High
Pancreatic Cancer 263 99.56 Very High Very High Very High
Rheumatoid Arthritis 100 99.26 Very High Very High Very High
Wound Healing 66 98.60 Very High Very High Very High
Fibrosis 65 98.04 Very High Very High Very High
Cicatrix 65 97.96 Very High Very High Very High
Targeted Disruption 433 97.56 Very High Very High Very High
Apoptosis 152 96.40 Very High Very High Very High
Injury 371 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF was found to be immunolocalized in proliferative zone cells and in some parietal cells in the gastric oxyntic mucosa (Fig 5).
Localization (immunolocalized) of EGF in parietal cells
1) Confidence 0.71 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.10 Pain Relevance 0
Although, our study showed the effect of EGF on wound healing & scar formation, one limitation of the experimental design of this study should be addressed regarding the application of EGF.
Localization (application) of EGF associated with cicatrix and wound healing
2) Confidence 0.63 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.15 Pain Relevance 0
The release of epidermal growth factor (EGF) from the submandibular salivary gland has been shown to promote mouse mammary tumorigenesis in virus mediated and chemical carcinogen induced models (Kurachi et al. 1985; Molinolo et al. 1998).
Localization (release) of epidermal growth factor in salivary gland
3) Confidence 0.57 Published 2007 Journal Transgenic Res Section Body Doc Link PMC1829418 Disease Relevance 0.65 Pain Relevance 0
The release of epidermal growth factor (EGF) from the submandibular salivary gland has been shown to promote mouse mammary tumorigenesis in virus mediated and chemical carcinogen induced models (Kurachi et al. 1985; Molinolo et al. 1998).
Localization (release) of EGF in salivary gland
4) Confidence 0.57 Published 2007 Journal Transgenic Res Section Body Doc Link PMC1829418 Disease Relevance 0.65 Pain Relevance 0
In rats, EGF-R was localized at the top-pit region and in the chief cell clusters at the bottom of the gastric glands [15].
Localization (localized) of EGF-R in chief cell
5) Confidence 0.49 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.67 Pain Relevance 0.24
No significant differences in the expression of total EGF receptor or ErbB4 proteins were observed between controls and HB-EGF KO mice (P>0.05 vs. control mice) (Fig. 6a and b).
Localization (receptor) of EGF associated with targeted disruption
6) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.70 Pain Relevance 0.05
The precursor cells were highly susceptible to the presence of EGF.
Localization (presence) of EGF in precursor cells
7) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
geo lineage selection with G418 [31,37] for 48 h to enrich for neural precursors, then dissociated and cultured in the presence of FGF-2 and EGF without serum.
Localization (presence) of EGF in neural
8) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
Simultaneous removal of EGF and FGF-2 on laminin results in astrocyte differentiation (unpublished data).
Localization (removal) of EGF in astrocyte
9) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0.51 Pain Relevance 0
EGF-R was localized heavily in the lower chief cell cluster region and moderately in the mucous neck cell region and in the foveolar pit region in both the WT and TG mucosae (Figure 1e), as was reported previously for the rat gastric mucosa [15].
Localization (localized) of EGF-R in pit associated with targeted disruption
10) Confidence 0.46 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.61 Pain Relevance 0
Since both the precursor and processed forms were equally active for stimulating EGF-R [28], we further examined EGF-R localization in the mucosa.
Spec (examined) Localization (localization) of EGF-R
11) Confidence 0.46 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.56 Pain Relevance 0
The epithelium secretes growth factors (e.g., HB-EGF, TGF-?)
Localization (secretes) of EGF in epithelium
12) Confidence 0.44 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.60 Pain Relevance 0.10
Growth factors stain in patches that do not correlate with the more sparse staining patterns of the TAF markers themselves due to the fact that the tumor cells also secrete the growth factors HGF, IL-6 and EGF in the presence of MSC as demonstrated by in vitro co-culture data (Figure S4).


Localization (secrete) of EGF in HGF associated with cancer
13) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.35 Pain Relevance 0.04
Patients with early RA had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF and bFGF when compared with patients with established RA (Figs 1 and 2, and Table 2).
Localization (levels) of EGF associated with rheumatoid arthritis
14) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.21 Pain Relevance 0.94
We confirmed the presence of HGF, EGF and IL-6 within the tumor stimulated MSC population that we identify as TAF.
Localization (presence) of EGF in HGF associated with cancer
15) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.25 Pain Relevance 0
To confirm the importance of huMSC-secreted EGF and IL-6 on Skov-3 cell proliferation, we co-cultured huMSC and rLuc/RFP labeled Skov-3 in vitro and immunoprecipitated (IP) EGF and/or IL-6 out of solution (individually and in combination).
Localization (secreted) of EGF
16) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.33 Pain Relevance 0
In any case our cultures do not sustain conditions for the genesis of neurons from astroglia (even in the presence of EGF/FGF2) without forced expression of neurogenic fate determinants.
Localization (presence) of EGF in neurons
17) Confidence 0.30 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.07
In pancreatic cancer, coexpression of the epidermal growth factor (EGF) receptor and EGF and/or transforming growth factor (TGF)-?
Localization (receptor) of EGF associated with pancreatic cancer
18) Confidence 0.29 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.05 Pain Relevance 0
In addition to these two major classes of agents, other strategies targeting the epidermal growth factor (EGF) pathway are in preclinical and early clinical phases of development.
Localization (targeting) of epidermal growth factor
19) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.38 Pain Relevance 0
In addition to these two major classes of agents, other strategies targeting the epidermal growth factor (EGF) pathway are in preclinical and early clinical phases of development.
Localization (targeting) of EGF
20) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.38 Pain Relevance 0

General Comments

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