INT172965

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Anatomy Link Frequency
chondrocyte 2
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 48.80 Quite Low
Inflammation 4 48.24 Quite Low
fibrosis 1 43.56 Quite Low
depression 9 5.00 Very Low Very Low Very Low
antiepileptic Drug 7 5.00 Very Low Very Low Very Low
Lamotrigine 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 14 98.44 Very High Very High Very High
Repression 4 93.84 High High
Pancreatic Cancer 57 91.84 High High
Apoptosis 23 91.12 High High
Sarcoma 5 88.24 High High
Death 9 87.12 High High
Osteochondroma 40 82.48 Quite High
Cancer 140 69.96 Quite High
Metastasis 11 65.56 Quite High
Colon Cancer 8 52.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, activation of FGFR3 in the proliferative zone (Fig. 5), by FGF18 [84] inhibits chondrocyte proliferation via phosphorylation of STAT-1 and subsequent upregulation of p21WAF/CIP1, which can inhibit the cell cycle [85].
Negative_regulation (inhibits) of Positive_regulation (upregulation) of p21WAF in chondrocyte
1) Confidence 0.41 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.38 Pain Relevance 0
G1 cell cycle arrest is, in most cases, a result of the induction of the CDKN1A gene, which encodes the cyclin-dependent kinase inhibitor WAF1 (also known as p21; Richon et al. 2000).
Negative_regulation (inhibitor) of Positive_regulation (induction) of CDKN1A gene
2) Confidence 0.14 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.31 Pain Relevance 0
Interestingly, Smad4/DPC4 also leads to the induction of p21/WAF1 so that Smad4 can contribute to the inhibition of cell cycle via the activation of WAF1 [14].
Negative_regulation (inhibition) of Positive_regulation (activation) of WAF1
3) Confidence 0.10 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.57 Pain Relevance 0
In addition to this, while VPA treatment in the cell lines is followed by a decrease of c-myc and an induction of p21, it has been observed that in primary AML cells, only the systematic decrease of c-myc is maintained, without upregulation of p21 expression.
Negative_regulation (decrease) of Positive_regulation (induction) of p21 associated with myeloid leukemia
4) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.59 Pain Relevance 0

General Comments

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