INT172971

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.77
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad6) intracellular (Smad6)
Anatomy Link Frequency
chondrocytes 1
Smad6 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 70.00 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 47 99.32 Very High Very High Very High
Hypertrophy 5 96.84 Very High Very High Very High
Pancreatic Cancer 57 91.44 High High
Targeted Disruption 4 81.12 Quite High
Metastasis 7 74.32 Quite High
Osteoarthritis 96 70.00 Quite High
Disease 13 69.56 Quite High
Aging 13 57.88 Quite High
Adenocarcinoma 1 23.72 Low Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking the Smad1/5/8 route by overexpression of Smad6 reduced the expression of both type X collagen and alkaline phosphatase activity in chondrocytes, while using Smad6 antisense had an opposite effect [67].
Gene_expression (overexpression) of Smad6 in chondrocytes
1) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.53 Pain Relevance 0.04
Following transfections with Smad6 and Smad7, a complete blockade of the growth-inhibitory effects of TGF-?
Gene_expression (transfections) of Smad6
2) Confidence 0.27 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.24 Pain Relevance 0

General Comments

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