INT172976

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Context Info
Confidence 0.00
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) signal transduction (Mras) nucleus (Smad4)
intracellular (Smad4) plasma membrane (Mras) DNA binding (Smad4)
Anatomy Link Frequency
epithelial cells 2
Mras (Mus musculus)
Smad4 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 61.36 Quite High
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 57 94.52 High High
Colon Cancer 2 65.24 Quite High
Pancreatitis 4 61.36 Quite High
Retinoblastoma 1 46.92 Quite Low
Apoptosis 3 35.04 Quite Low
Microsatellite Instability 1 23.28 Low Low
Cancer 46 19.00 Low Low
Stomach Cancer 1 18.08 Low Low
Hyperplasia 1 10.84 Low Low
Metastasis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
ras-protein Regulation (through) of Gene_expression (expression) of DPC4 in epithelial cells
1) Confidence 0.00 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12

General Comments

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