INT172977

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Context Info
Confidence 0.00
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.39
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cdkn1a, Inca1) cytoplasm (Cdkn1a, Inca1) cytosol (Cdkn1a)
molecular_function (Inca1) cell cycle (Cdkn1a) kinase activity (Cdkn1a)
Cdkn1a (Mus musculus)
Inca1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 76.48 Quite High
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 97.88 Very High Very High Very High
Apoptosis 3 94.92 High High
Pancreatic Cancer 57 89.44 High High
Cancer 46 78.88 Quite High
Pancreatitis 4 76.48 Quite High
Hyperplasia 1 70.72 Quite High
Malignant Neoplastic Disease 4 63.32 Quite High
Colon Cancer 2 59.36 Quite High
Adhesions 1 22.88 Low Low
Metastasis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WAF1, that is activated by wild type p53, but not by mutated p53, inhibits the activation of cyclin-CDK complex and the phosphorylation and inactivation of Retinoblastoma proteins thereby stopping the progression of cell cycle in phase G1.
WAF1 Negative_regulation (inhibits) of Positive_regulation (activation) of cyclin-CDK associated with retinoblastoma
1) Confidence 0.00 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.39 Pain Relevance 0.27

General Comments

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