INT172978

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2)
intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)
Anatomy Link Frequency
quadriceps 1
epithelial cells 1
SMAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
long-term potentiation 7 71.64 Quite High
nMDA receptor 2 65.36 Quite High
Chronic pancreatitis 4 60.12 Quite High
ketamine 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 57 93.28 High High
Hypertrophy 36 77.04 Quite High
Colon Cancer 2 64.00 Quite High
Pancreatitis 4 60.12 Quite High
Retinoblastoma 1 45.68 Quite Low
Lifespan 4 39.44 Quite Low
Apoptosis 10 33.80 Quite Low
Hyperplasia 19 27.28 Quite Low
Microsatellite Instability 1 20.32 Low Low
Cancer 48 17.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In C57 Bl/6 mice overexpressing dnMstat there was a decrease in the levels of phosphorylated Smad 2/3 as was seen in C2C12 cells incubated with anti-myostatin antibody [3].
Negative_regulation (decrease) of Smad 2
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.08 Pain Relevance 0
In treated quadriceps there was a decrease in phosphorylated Smad 2/3, a decrease in phosphorylated JNK and an increase in phosphorylated Akt (n?
Negative_regulation (decrease) of Smad 2 in quadriceps
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0 Pain Relevance 0
The formed smad2/3-smad4 factor is mutually inhibited with PPAR-alpha-RXR-alpha complex.
Negative_regulation (inhibited) of smad2
3) Confidence 0.42 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.16
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Negative_regulation (inhibition) of Smad2 in epithelial cells
4) Confidence 0.41 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.82 Pain Relevance 0.12

General Comments

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