INT17299

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Context Info
Confidence 0.05
First Reported 1991
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) peptidase activity (Prss12)
lipid metabolic process (Acot1) cytoplasm (Acot1)
Anatomy Link Frequency
brain 2
hippocampus 2
Prss12 (Rattus norvegicus)
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 9 99.76 Very High Very High Very High
gABA 22 99.20 Very High Very High Very High
Glutamate 10 99.20 Very High Very High Very High
antagonist 7 98.52 Very High Very High Very High
Hippocampus 12 96.80 Very High Very High Very High
Substantia nigra 1 96.40 Very High Very High Very High
tetrodotoxin 4 94.36 High High
GABAergic 4 85.36 High High
interneuron 1 56.72 Quite High
dopamine receptor 1 40.88 Quite Low
Disease Link Frequency Relevance Heat
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These lesions did not alter the NT regulation of potassium-evoked ACh release from striatal slices, but did significantly increase spontaneous (33%) and potassium-evoked (40%) ACh release from striatal slices.
NT Regulation (regulation) of Localization (release) of ACh
1) Confidence 0.05 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.31
The effect of NT on the release of ACh was blocked by the GABA(A) receptor antagonist bicuculline (2-10 microM).
NT Regulation (effect) of Localization (release) of ACh associated with gaba and antagonist
2) Confidence 0.03 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 1.12
The effects of neurotensin (NT) on the release of acetylcholine (ACh), aspartate (Asp), glutamate (Glu) and gamma-aminobutyric acid (GABA) from the hippocampus of freely moving rats were studied by transversal microdialysis.
NT Regulation (effects) of Localization (release) of ACh in hippocampus associated with gaba, glutamate and hippocampus
3) Confidence 0.03 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 0.44
The effect of neurotensin (NT) on the release of acetylcholine (ACh) and dopamine (DA) from striatal slices of the rat brain was studied.
NT Regulation (effect) of Localization (release) of ACh in brain associated with dopamine
4) Confidence 0.02 Published 1993 Journal Brain Res. Section Abstract Doc Link 8101133 Disease Relevance 0 Pain Relevance 0.21

General Comments

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