INT172996

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2003
Last Reported 2008
Negated 4
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 11.01
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC2)
Anatomy Link Frequency
pancreas 1
glands 1
MUC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 64 92.44 High High
agonist 27 86.96 High High
Inflammation 51 84.00 Quite High
Chronic pancreatitis 105 74.80 Quite High
imagery 40 64.88 Quite High
tetrodotoxin 1 63.80 Quite High
Inflammatory response 3 32.40 Quite Low
Serotonin 1 8.80 Low Low
bradykinin 3 8.36 Low Low
Inflammatory mediators 4 5.88 Low Low
Disease Link Frequency Relevance Heat
Infection 46 100.00 Very High Very High Very High
Metaplasia 1 100.00 Very High Very High Very High
Cancer 512 99.92 Very High Very High Very High
Pulmonary Disease 51 99.80 Very High Very High Very High
Breast Cancer 194 98.76 Very High Very High Very High
Asthma 39 97.54 Very High Very High Very High
Adenocarcinoma 121 97.28 Very High Very High Very High
Aggression 4 94.08 High High
Gastritis 19 93.32 High High
Carcinoma 22 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IPMNs with a high expression of MUC2 and MUC5AC have a lower invasion and metastasising potential in comparison to DACs and therefore a better clinical outcome [36-39].
Gene_expression (expression) of MUC2
1) Confidence 0.69 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.80 Pain Relevance 0
The third group with an oncocytic histology is characterized by a focal MUC1 and MUC2 expression [36].
Gene_expression (expression) of MUC2
2) Confidence 0.69 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.78 Pain Relevance 0
Studies revealed that IPMNs in general express MUC2, MUC5AC and mostly MUC4 whereas MUC1 is absent [36-39].
Neg (absent) Gene_expression (express) of MUC2
3) Confidence 0.69 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.88 Pain Relevance 0
A recent study has shown that non-invasive MCNs can be distinguished from IPMNs and DACs by the mucin profile that is characterized by expression of MUC5AC, whereas MUC2 expression is restricted to globlet cells [40].
Gene_expression (expression) of MUC2 associated with cancer
4) Confidence 0.69 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.31 Pain Relevance 0.11
In addition, no MUC2, MUC4, or MUC7 expression was detected in normal pancreas.


Gene_expression (expression) of MUC2 in pancreas
5) Confidence 0.69 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.81 Pain Relevance 0
The largest group is MUC2 positive and MUC1 negative.
Neg (negative) Gene_expression (positive) of MUC2
6) Confidence 0.60 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.75 Pain Relevance 0
A second group of IPMNs is MUC1 positive and MUC2 negative with an increased tendency for invasion and seems to be related to DAC.
Neg (negative) Gene_expression (negative) of MUC2 associated with adenocarcinoma
7) Confidence 0.54 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.65 Pain Relevance 0
Both secreted (MUC2, MUC5AC, MUC5B, and MUC7) and membrane bound (MUC1, MUC4, and MUC16) mucin forms have been reported to be expressed by ocular surface epithelia [6,21,22].
Gene_expression (expressed) of MUC2
8) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0 Pain Relevance 0
MUC2 and MUC5B are present in very low quantities [21-23].
Gene_expression (present) of MUC2
9) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0 Pain Relevance 0
The apomucines MUC5AC and MUC6 were positive in more than 50% of neoplastic cells, indicating a gastric foveolar phenotype while CDX2 and MUC2 were negative, indicating that intestinal phenotype was completely absent; also MUC1 was negative.
Neg (negative) Gene_expression (negative) of MUC2
10) Confidence 0.48 Published 2008 Journal Cases J Section Body Doc Link PMC2613149 Disease Relevance 0.42 Pain Relevance 0.04
Immunostaining for MUC1, MUC2, MUC5AC, MUC6, CDX2, CK-7, and CK-20 were performed on sections specimens that were dewaxed and rehydrated using Bio-clear (Bio-Optica, Milan, Italy) and graded alcohols.
Gene_expression (Immunostaining) of MUC2
11) Confidence 0.42 Published 2008 Journal Cases J Section Body Doc Link PMC2613149 Disease Relevance 0.19 Pain Relevance 0.09
In a study by Rakha and colleagues [56], expression of a number of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) were profiled by TMA in 1447 cases of invasive breast cancer in order to evaluate their prognostic significance.
Gene_expression (expression) of MUC2 associated with breast cancer
12) Confidence 0.40 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.19 Pain Relevance 0
Overexpression of MUC1 along with MUC2 and MUC3 has been detected in breast cancer [55].
Gene_expression (Overexpression) of MUC2 associated with breast cancer
13) Confidence 0.31 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.47 Pain Relevance 0
The composition of mucus in asthma and COPD is generally altered, with higher expression of the low charge isoform MUC5B, particularly in COPD, and with the expression of small amounts of the insoluble MUC2; in COPD the ratio of mucus cells to serous cells in the submucosal glands is also increased [69].
Gene_expression (expression) of MUC2 in glands associated with asthma and pulmonary disease
14) Confidence 0.25 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.87 Pain Relevance 0.15
The observed shifts in glycosylation were not due to pre-dysplastic alterations of the gastric mucosa such as intestinal metaplasia, because the spatial distribution of expression patterns for the two common gastric mucins MUC5AC and MUC6 (Figure S3) were unchanged during the 10-month period of experimental infection, with no aberrant MUC2 or atypical sulfo-mucins being detected (data not shown).


Gene_expression (alterations) of MUC2 associated with metaplasia and infection
15) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox