INT172999

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 8.91
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC4) cell adhesion (MUC4) proteinaceous extracellular matrix (MUC4)
plasma membrane (MUC4) biological_process (MUC4)
Anatomy Link Frequency
covering 2
pancreatic duct 2
MUC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 16 96.68 Very High Very High Very High
Chronic pancreatitis 31 89.60 High High
Inflammation 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 8 99.68 Very High Very High Very High
Cancer 421 99.04 Very High Very High Very High
Pancreatic Cancer 211 98.84 Very High Very High Very High
Adhesions 34 98.12 Very High Very High Very High
Metastasis 72 97.60 Very High Very High Very High
Disease Progression 4 96.68 Very High Very High Very High
Adenocarcinoma 133 95.16 Very High Very High Very High
Apoptosis 24 94.44 High High
Repression 4 93.92 High High
Malignant Neoplastic Disease 69 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing expression of MUC4 with an increasing grade of PanIN supports the assumption of PanIN being a precursor for infiltrating pancreatic ductal adenocarcinoma.
Positive_regulation (Increasing) of Gene_expression (expression) of MUC4 associated with adenocarcinoma
1) Confidence 0.59 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 1.17 Pain Relevance 0.16
A recent study on 71 PanIN lesions of different grades and 28 invasive carcinomas shows a steady increase in MUC4 expression along with the increase in severity of pancreatic duct lesion [67,68].
Positive_regulation (increase) of Gene_expression (expression) of MUC4 in pancreatic duct associated with carcinoma
2) Confidence 0.59 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 1.22 Pain Relevance 0.13
The fact that elevated MUC4 expression occurs in the majority (70-80%) of pancreatic carcinomas, most notably at early onset of disease progression, leads to the discussion of MUC4 as a new tumor marker for this deadly disease [47].
Positive_regulation (elevated) of Gene_expression (expression) of MUC4 associated with cancer, pancreatic cancer, disease and disease progression
3) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.43 Pain Relevance 0.21
In addition to its involvement in the covering of luminal epithelia, recent studies suggest that the overexpression of the MUC4 rat homologue sialomucin complex (SMC) disrupts integrin-mediated cell-matrix and cell-cell interaction and inhibits immune recognition [33].
Positive_regulation (overexpression) of Gene_expression (overexpression) of MUC4 in covering
4) Confidence 0.48 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.73 Pain Relevance 0.06
Increasing expression of MUC4 with an increasing grade of PanIN supports the assumption of PanIN being a precursor for infiltrating pancreatic ductal adenocarcinoma.
Positive_regulation (Increasing) of Gene_expression (expression) of MUC4 associated with adenocarcinoma
5) Confidence 0.43 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 1.17 Pain Relevance 0.16
The top hits of overexpressed genes (fold change > 10) were Mucin 4 (MUC4) and some family members of the carcinoembryonic antigen-related adhesion molecules (CEACAM 1, CEACAM 5 and CEACAM 6).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MUC4 associated with adhesions
6) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.28 Pain Relevance 0.25
The fact that elevated MUC4 expression occurs in the majority (70-80%) of pancreatic carcinomas, most notably at early onset of disease progression, leads to the discussion of MUC4 as a new tumor marker for this deadly disease [47].
Positive_regulation (occurs) of Gene_expression (expression) of MUC4 associated with cancer, pancreatic cancer, disease and disease progression
7) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.43 Pain Relevance 0.21
The highest overexpression concerned the surface protein Mucin 4 (MUC4), which is involved in the regulation of cell adhesion.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MUC4 associated with adhesions
8) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.47 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox