INT17300

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Context Info
Confidence 0.11
First Reported 1991
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) peptidase activity (Prss12)
lipid metabolic process (Acot1) cytoplasm (Acot1)
Anatomy Link Frequency
substantia nigra 2
Prss12 (Rattus norvegicus)
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 22 100.00 Very High Very High Very High
Substantia nigra 2 99.92 Very High Very High Very High
Glutamate 10 99.40 Very High Very High Very High
agonist 1 99.04 Very High Very High Very High
tetrodotoxin 5 98.16 Very High Very High Very High
antagonist 9 96.24 Very High Very High Very High
Dopamine 12 95.80 Very High Very High Very High
Hippocampus 12 88.48 High High
GABAergic 4 82.16 Quite High
interneuron 2 50.40 Quite High
Disease Link Frequency Relevance Heat
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second set of experiments tested the effects of 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra on NT-induced increases of potassium-evoked ACh release.
NT Positive_regulation (increases) of Localization (release) of ACh in substantia nigra associated with substantia nigra
1) Confidence 0.11 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.32
NT enhanced potassium (25 mM)-evoked ACh release from striatal slices in a dose-dependent manner.
NT Positive_regulation (enhanced) of Localization (release) of ACh
2) Confidence 0.09 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.31
Local infusion of tetrodotoxin (1 microM) decreased the basal release of ACh, GABA, Asp, Glu and prevented the 0.2 microM NT-induced increase in GABA and ACh release.
NT Positive_regulation (increase) of Localization (release) of ACh associated with tetrodotoxin, glutamate and gaba
3) Confidence 0.04 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 1.13
Local infusion of tetrodotoxin (1 microM) decreased the basal release of ACh, GABA, Asp, Glu and prevented the 0.2 microM NT-induced increase in GABA and ACh release.
NT Positive_regulation (induced) of Localization (release) of ACh associated with tetrodotoxin, glutamate and gaba
4) Confidence 0.04 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 1.13
However, the D2 receptor agonist quinpirole, 0.01 mM, significantly reduced the NT-induced release of ACh by 77%.
NT Positive_regulation (induced) of Localization (release) of ACh associated with agonist
5) Confidence 0.03 Published 1993 Journal Brain Res. Section Abstract Doc Link 8101133 Disease Relevance 0 Pain Relevance 0.40

General Comments

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