INT173003

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.27
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
epithelial cells 6
eye 2
fibroblast 2
goblet cell 2
glands 2
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 98.84 Very High Very High Very High
dexamethasone 28 98.60 Very High Very High Very High
cytokine 24 92.24 High High
chemokine 12 85.28 High High
Chronic pancreatitis 15 80.44 Quite High
tolerance 5 76.48 Quite High
agonist 26 46.08 Quite Low
Central nervous system 2 42.40 Quite Low
corticosteroid 3 37.92 Quite Low
peptic ulcer disease 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 89 100.00 Very High Very High Very High
Pancreatic Cancer 33 100.00 Very High Very High Very High
Syndrome 161 99.84 Very High Very High Very High
Infection 147 99.76 Very High Very High Very High
Eye Disease 29 99.40 Very High Very High Very High
Dry Eye 103 99.24 Very High Very High Very High
Nicotine Addiction 133 98.94 Very High Very High Very High
INFLAMMATION 48 98.84 Very High Very High Very High
Pulmonary Disease 64 97.88 Very High Very High Very High
Asthma 42 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our demonstration of progressive depletion of cellular MUC1 is consistent with a previous study where MUC1 expression decreased in Kato III cells after 4 h of co-culture with H. pylori (with unknown adhesion properties) [33].
Negative_regulation (decreased) of Gene_expression (expression) of MUC1 associated with adhesions
1) Confidence 0.57 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.23 Pain Relevance 0
Data on other membrane bound mucins has suggested that the expression of mucosal epithelial membrane mucin (as detected by an uncharacterized antibody referred to as AMEM2), is reduced in SS and non-SS dry eyed subjects compared to normals [47].
Negative_regulation (reduced) of Gene_expression (expression) of mucin associated with syndrome
2) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.04 Pain Relevance 0
Data on other membrane bound mucins has suggested that the expression of mucosal epithelial membrane mucin (as detected by an uncharacterized antibody referred to as AMEM2), is reduced in SS and non-SS dry eyed subjects compared to controls [34].
Negative_regulation (reduced) of Gene_expression (expression) of mucin associated with syndrome
3) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.14 Pain Relevance 0
The rapid decrease in MUC1 protein with sustained levels of MUC1 mRNA, suggest that loss of protein rather than decreased MUC1 production is the likely explanation for MUC1 depletion from the cell.
Negative_regulation (decreased) of Gene_expression (production) of MUC1
4) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.05 Pain Relevance 0
During the initial contact with gastric cells, MUC1 inhibits adhesion of both MUC1-binding and non MUC1-binding H. pylori to epithelial cells.
Negative_regulation (inhibits) of Gene_expression (adhesion) of MUC1-binding in epithelial cells associated with adhesions
5) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.50 Pain Relevance 0
During the initial contact with gastric cells, MUC1 inhibits adhesion of both MUC1-binding and non MUC1-binding H. pylori to epithelial cells.
Negative_regulation (inhibits) of Gene_expression (adhesion) of MUC1-binding in epithelial cells associated with adhesions
6) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.50 Pain Relevance 0
With loss of tear volume, lipid layer, glycocalyx mucins and/or gel forming mucins, dry spots develop on the eye, leading to keratinisation and loss of mucin gene expression by the epithelial cells.
Negative_regulation (loss) of Gene_expression (expression) of mucin in epithelial cells
7) Confidence 0.38 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1859988 Disease Relevance 0.26 Pain Relevance 0
Others have explored transmembrane mucin expression in SS and dry eye disease.
Negative_regulation (explored) of Gene_expression (expression) of mucin in eye associated with syndrome and eye disease
8) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.92 Pain Relevance 0
Mucin gene expression in intraductal papillary-mucinous pancreatic neoplasia and related lesions
Negative_regulation (lesions) of Gene_expression (expression) of Mucin gene associated with pancreatic cancer
9) Confidence 0.36 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.30 Pain Relevance 0.08
Infection results in progressive depletion of cellular MUC1 and binding of MUC1 to H. pylori
Negative_regulation (depletion) of Gene_expression (progressive) of MUC1 associated with infection
10) Confidence 0.36 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.10 Pain Relevance 0
cell infiltrate into normal tissues expressing MUC1 was observed,
Negative_regulation (tissues) of Gene_expression (expressing) of MUC1
11) Confidence 0.35 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.90 Pain Relevance 0.09
In our case, meningioma components of the lesion mixed atypical cells and clear cells with hypercellularity, higher mitotic activity and higher MIB-1 index which corresponded to WHO grade II; however, the fibroblast-like spindle cells disposed around the blood vessels were bland appearance with lower proliferation index and lacking EMA expression.
Negative_regulation (lacking) of Gene_expression (expression) of EMA in fibroblast associated with meningioma and hyperplasia
12) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2904739 Disease Relevance 1.05 Pain Relevance 0
The observed decrease in mucin stores in long-term ex-smokers with COPD, and its relation with duration of smoking cessation, can be explained by decreased goblet cell numbers, decreased mucin production, and/or increased mucin secretion.
Negative_regulation (decreased) of Gene_expression (production) of mucin in goblet cell associated with pulmonary disease and nicotine addiction
13) Confidence 0.07 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.63 Pain Relevance 0.03
2 effectively reduces mucin production and Gob-5 and Muc5-ac mRNA expression
Negative_regulation (reduces) of Gene_expression (production) of mucin
14) Confidence 0.01 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.59 Pain Relevance 0.59
Control glands have high levels of mucin-producing cells (pink staining in Fig. 5E), which is strongly reduced after irradiation (Fig. 5F).
Negative_regulation (reduced) of Gene_expression (producing) of mucin in glands
15) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2329592 Disease Relevance 0.06 Pain Relevance 0

General Comments

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