INT173005

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Context Info
Confidence 0.63
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.15
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
epithelial cells 4
mononuclear cell 1
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 9 99.30 Very High Very High Very High
dexamethasone 27 98.28 Very High Very High Very High
antagonist 5 94.08 High High
gABA 59 92.24 High High
cytokine 82 91.92 High High
GABAergic 46 89.72 High High
anesthesia 13 87.92 High High
epidural 1 87.48 High High
imagery 10 86.52 High High
chemokine 29 84.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 49 100.00 Very High Very High Very High
Pancreatic Cancer 33 100.00 Very High Very High Very High
Adenocarcinoma 22 100.00 Very High Very High Very High
Asthma 46 99.92 Very High Very High Very High
Syndrome 246 99.76 Very High Very High Very High
Sjoegrens Syndrome 155 99.16 Very High Very High Very High
Pancreatitis 21 98.60 Very High Very High Very High
Obstructive Airway Disease 1 93.36 High High
Metaplasia 9 92.88 High High
Hyperplasia 13 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Transcription (levels) of MUC1
1) Confidence 0.63 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.49
Soluble MUC1 expression was also higher in the KCS group compared to the NDE group (p=0.02), where as MUC1 mRNA expression was similar in both KCS and NDE groups.
Transcription (expression) of MUC1 associated with sjoegrens syndrome
2) Confidence 0.53 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927371 Disease Relevance 1.69 Pain Relevance 0
The SS group also expressed a significantly higher concentration of MUC1 mRNA compared to both KCS (3.18±1.44 [SS]; 1.79±1.18 [KCS]; p<0.05) and NDE (1.60±0.75 [NDE]; p<0.05) groups (Figure 3).
Transcription (expressed) of MUC1 associated with sjoegrens syndrome and syndrome
3) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.77 Pain Relevance 0.07
The SS group also expressed a significantly higher concentration of MUC1 mRNA compared to both KCS (3.18±1.44 [SS]; 1.79±1.18 [KCS]; p<0.05) and NDE (1.60±0.75 [NDE]; p<0.05) groups (Figure 3).
Transcription (concentration) of MUC1 associated with sjoegrens syndrome and syndrome
4) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.75 Pain Relevance 0.07
To quantify and compare human mucin 1 (MUC1) protein and mRNA expression in tears and conjunctival epithelial cells collected from Sjogren’s syndrome (SS), non-Sjogren’s keratoconjunctivitus sicca (KCS) and non-dry eyed (NDE) control subjects.


Transcription (expression) of MUC1 in epithelial cells associated with sjoegrens syndrome and syndrome
5) Confidence 0.53 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927371 Disease Relevance 0.62 Pain Relevance 0
However, MUC1 mRNA levels increased progressively in culture but were not significantly affected by the presence of H. pylori (Figure 5B).
Transcription (levels) of MUC1
6) Confidence 0.52 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.12 Pain Relevance 0
MUC, mucin; RT-PCR, reverse transcription polymerase chain reaction; PBMC, peripheral blood mononuclear cell; PanIN, pancreatic intraepithelial neoplasia; IPMT, intraductal papillary-mucinous tumors; IPMN, intraductal papillary-mucinous neoplasia; DAC, ductal adenocarcinoma; MCN, moucinous cystic neoplasms

Authors' contribution

Transcription (contribution) of mucin in mononuclear cell associated with adenocarcinoma, cancer and pancreatic cancer
7) Confidence 0.51 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.48 Pain Relevance 0.19
To quantify and compare human mucin 1 (MUC1) protein and mRNA expression in tears and conjunctival epithelial cells collected from Sjogren’s syndrome (SS), non-Sjogren’s keratoconjunctivitus sicca (KCS) and non-dry eyed (NDE) control subjects.


Transcription (expression) of mucin in epithelial cells associated with sjoegrens syndrome and syndrome
8) Confidence 0.47 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927371 Disease Relevance 0.62 Pain Relevance 0
Fu et al [41] showed that incubation of rhesus macaque bronchial epithelial cells with nicotine for 48 hr significantly increased mucin mRNA levels.
Transcription (levels) of mucin in epithelial cells associated with nicotine
9) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.35 Pain Relevance 0.79
markedly increased the steady-state level of MUC2 mucin mRNA in ME epithelial cells of rats in a dose- and time-dependent manner (237).
Transcription (level) of mucin in epithelial cells
10) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.80 Pain Relevance 0.04
2 effectively reduces mucin production and Gob-5 and Muc5-ac mRNA expression
Transcription (expression) of mucin
11) Confidence 0.01 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.60 Pain Relevance 0.59

General Comments

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