INT17302

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.56
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp8a1)
Anatomy Link Frequency
macrophages 1
B cells 1
NK cell 1
spleen 1
parenchyma 1
Atp8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 4 92.36 High High
cytokine 27 91.16 High High
Inflammation 90 90.40 High High
Root ganglion neuron 1 81.24 Quite High
tolerance 10 77.36 Quite High
rheumatoid arthritis 54 65.24 Quite High
alcohol 26 50.00 Quite Low
anesthesia 6 44.08 Quite Low
ketamine 5 43.12 Quite Low
Central nervous system 29 38.56 Quite Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 51 99.44 Very High Very High Very High
Targeted Disruption 17 95.24 Very High Very High Very High
Experimental Autoimmune Neuritis 4 92.36 High High
INFLAMMATION 88 90.40 High High
Infection 4 87.40 High High
Apoptosis 43 82.12 Quite High
Ganglion Cysts 1 80.92 Quite High
Impaired Glucose Tolerance 10 77.36 Quite High
Stress 13 72.64 Quite High
Hypersensitivity 5 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In brief, using the albino Friend Virus-B type (FVB) mice, the cDNA for murine class I ADH was inserted behind mouse ?
Positive_regulation (murine) of class I
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.73 Pain Relevance 0
In brief, using the albino Friend Virus-B type (FVB) mice, the cDNA for murine class I ADH was inserted behind mouse ?
Positive_regulation (murine) of class I
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.35 Pain Relevance 0.04
Haplotype B homozygotes had lower levels of MHC class I expressed on the surface of B cells, suggesting that naturally occurring ERAP2 deficiency affects MHC presentation and immune response.
Positive_regulation (levels) of class I in B cells
3) Confidence 0.49 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
Control LNC from animals injected with Freund's adjuvant alone or naive spleen cells did not induce MHC class II.
Neg (not) Positive_regulation (induce) of class I in spleen
4) Confidence 0.45 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1899426 Disease Relevance 0.43 Pain Relevance 0.39
This class I-related antigen is a powerful NKG2D ligand for NK cell-mediated antitumor immunity induction, whereas the DR alpha chain is crucial for antigen presentation within the context of class II MHC [95,49,50].
Positive_regulation (induction) of class I in NK cell
5) Confidence 0.45 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.13 Pain Relevance 0
They activate macrophages to produce reactive oxygen intermediates and nitric oxide, stimulate their phagocytic functions, and enhance their ability for antigen presentation by upregulating MHC class II molecules.
Positive_regulation (upregulating) of class I in macrophages
6) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.40 Pain Relevance 0.28
In addition to the increased number of immunocompetent cells present in the CVOs during EAE, we observed a significant upregulation of major histocompatibility complex (MHC) antigens class I on cells throughout the entire parenchyma of the CVOs, where expression was absent before in healthy mice (Figs. 4, 6 and Table 1).
Positive_regulation (upregulation) of class I in parenchyma associated with multiple sclerosis
7) Confidence 0.01 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.52 Pain Relevance 0.08

General Comments

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