INT173021

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 10.73
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC5AC) cell adhesion (MUC5AC)
Anatomy Link Frequency
tear 5
goblet cells 2
blood 1
pancreatic duct 1
MUC5AC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 152 98.98 Very High Very High Very High
dexamethasone 46 98.88 Very High Very High Very High
metalloproteinase 21 97.80 Very High Very High Very High
abdominal pain 1 90.80 High High
Inflammatory response 18 73.72 Quite High
fibrosis 7 52.56 Quite High
Chronic pancreatitis 30 41.56 Quite Low
topical agent 5 40.68 Quite Low
corticosteroid 3 37.52 Quite Low
cytokine 67 30.48 Quite Low
Disease Link Frequency Relevance Heat
Otitis Media With Effusion 92 100.00 Very High Very High Very High
Mycobacterial Infection 79 100.00 Very High Very High Very High
Disease 86 99.24 Very High Very High Very High
Glaucoma 130 99.12 Very High Very High Very High
Metaplasia 22 99.06 Very High Very High Very High
INFLAMMATION 191 98.98 Very High Very High Very High
Syndrome 206 98.92 Very High Very High Very High
Eye Disease 38 96.64 Very High Very High Very High
Sprains And Strains 67 94.80 High High
Adhesions 41 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For MUC5AC, which is secreted solely by conjunctival goblet cells, this indicates that, even for a relatively short-term topical anti-glaucoma medication therapy, the goblet cells of the patients may be decreased considerably, numerically and/or functionally.
Localization (secreted) of MUC5AC in goblet cells associated with glaucoma
1) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.34 Pain Relevance 0
In our study, we also detected a decrease of MUC5AC in the tear fluid after phacotrabeculectomy, which probably resulted from the conjunctival squamous metaplasia and the reduction of goblet cell density, for MUC5AC of the tear fluid is secreted uniquely by the conjunctival goblet cells.
Localization (secreted) of MUC5AC in tear associated with metaplasia
2) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.93 Pain Relevance 0.09
In a recent study, overexpression of MUC6 and the de novo expression of gastric secretory mucin MUC5AC in all stages of PanINs and in invasive DACs was described on RNA and protein level [22].
Localization (secretory) of MUC5AC
3) Confidence 0.67 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.85 Pain Relevance 0
Certainly, the secreted mucin MUC5AC has been shown to be reduced in SS tears and conjunctival cells [29].
Localization (secreted) of MUC5AC in tears associated with syndrome
4) Confidence 0.66 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.27 Pain Relevance 0
MUC5AC change of the patients after phacotrabeculectomy
Localization (change) of MUC5AC
5) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.13 Pain Relevance 0
The MUC5AC decreased significantly from 16.95±12.86 ng/ml before surgery to 6.91±7.11 (range from 1.11 to 27.37) ng/ml 1 month after surgery (paired samples t test, t=4.93, p<0.05).
Localization (decreased) of MUC5AC
6) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.11 Pain Relevance 0
In our study, we demonstrated a significant decrease of MUC5AC in the tear fluid of PACG patients after short-term anti-glaucoma medications or phacotrabeculectomy, and this indicates that, for these patients, more attention should be paid to the maintenance or recover of their tear film stability and ocular surface physiology.



Localization (decrease) of MUC5AC in tear associated with glaucoma
7) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.54 Pain Relevance 0.03
Both secreted (MUC2, MUC5AC, MUC5B, and MUC7) and membrane bound (MUC1, MUC4, and MUC16) mucin forms have been reported to be expressed by ocular surface epithelia [6,21,22].
Localization (secreted) of MUC5AC
8) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0 Pain Relevance 0
Studies using Northern blot analyses, in situ hybridization and immunohistochemistry did not show any MUC5AC in pancreatic duct cells [22,23].
Neg (not) Localization (show) of MUC5AC in pancreatic duct
9) Confidence 0.55 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.23 Pain Relevance 0
This report is intended to increase clinician awareness of late and atypical presentation of TBM.


Localization (presentation) of TBM associated with mycobacterial infection
10) Confidence 0.48 Published 2008 Journal Cases J Section Body Doc Link PMC2559826 Disease Relevance 1.49 Pain Relevance 0.09
On the ocular surface, the large secreted gel-forming mucin, human mucin 5AC (MUC5AC), is expressed by the goblet cells and hydrates in the tear film to act as a lubricating agent and clearing molecule [21,22].
Localization (secreted) of MUC5AC in tear
11) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0 Pain Relevance 0
This has been demonstrated most consistently with the findings of reduced secreted MUC5AC in the tears of Sjogren’s syndrome patients [32], and in their conjunctival cells [32,44] compared to normals.
Localization (secreted) of MUC5AC in tears associated with syndrome
12) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.29 Pain Relevance 0
These binding tests demonstrate that BabA positive bacteria co-localize with the MUC5AC mucin (compare Figure S3A and S3C).
Localization (localize) of MUC5AC mucin
13) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.53 Pain Relevance 0.14
Smirnova et al. (104) assessed the effects of IL-8 and other proinflammatory cyokines on goblet cells using human goblet cell line HT29-MTX which secretes two OME-related mucins, MUC5AC and MUC5B.
Localization (secretes) of MUC5AC in goblet cells associated with otitis media with effusion
14) Confidence 0.26 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.14 Pain Relevance 0.09
In the human stomach, the Leb blood-group antigen is mainly expressed by the surface epithelium and on the MUC5AC secreted mucin [11].
Localization (secreted) of MUC5AC in blood
15) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.25 Pain Relevance 0
Of these, the mucins are now classified into gel-forming or secreting, (e.g., MUC5), soluble, (e.g., MUC7), and transmembrane, (e.g., MUC1).
Localization (secreting) of MUC5
16) Confidence 0.18 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1859988 Disease Relevance 0.09 Pain Relevance 0
T) and thus are incomplete nonsecretors, producing small amounts of ABO and Leb HBGA in secretions.
Localization (secretions) of Leb
17) Confidence 0.04 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874438 Disease Relevance 1.08 Pain Relevance 0
Matrix metalloproteinases (MMPs) are important in the immunopathology of many inflammatory CNS diseases thus we hypothesized that that their secretion is important in TBM and might be influenced by dexamethasone.


Localization (secretion) of TBM associated with inflammation, metalloproteinase, disease and dexamethasone
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2748711 Disease Relevance 0.46 Pain Relevance 0.46

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