INT173022

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.59
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
eye 6
tear 2
pancreas 2
cleavage 2
T-cell 2
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 10 100.00 Very High Very High Very High
Chronic pancreatitis 15 94.52 High High
anesthesia 17 92.56 High High
Inflammation 24 76.28 Quite High
Inflammatory response 7 48.20 Quite Low
addiction 12 32.00 Quite Low
cva 2 19.32 Low Low
cytokine 17 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
peptic ulcer disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eye Disease 48 100.00 Very High Very High Very High
Dry Eye 130 99.84 Very High Very High Very High
Infection 33 99.68 Very High Very High Very High
Syndrome 255 99.50 Very High Very High Very High
Targeted Disruption 8 99.28 Very High Very High Very High
Cancer 83 98.76 Very High Very High Very High
Pancreatic Cancer 33 97.68 Very High Very High Very High
Pox Virus Infection 38 96.80 Very High Very High Very High
Adenocarcinoma 21 96.44 Very High Very High Very High
Sjoegrens Syndrome 140 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is possible that these VNTR length polymorphisms are surrogate markers for SNP's encoding functional changes in other domains (for example, SNPs affecting cytoplasmic domain signaling or cleavage of the extracellular domain) or promoter polymorphisms affecting the level of MUC1 expression during infection.
Regulation (affecting) of Gene_expression (expression) of MUC1 in cleavage associated with infection
1) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.37 Pain Relevance 0
Dry eye research has shown that the gel forming mucin MUC5AC, is a major factor in dry eye disease in that its expression is reduced in dry eye subjects [32].
Regulation (reduced) of Gene_expression (expression) of mucin in eye associated with dry eye and eye disease
2) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.37 Pain Relevance 0
proliferation in response to the MUC1 antigen by the
Regulation (response) of Gene_expression (antigen) of MUC1
3) Confidence 0.42 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.29 Pain Relevance 0
Antibody, but not T-cell tolerance to MUC1 has been observed in
Regulation (observed) of Gene_expression (Antibody) of MUC1 in T-cell associated with tolerance
4) Confidence 0.42 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.73 Pain Relevance 0.05
The observation of excess ocular mucus in SS patients and the results of this study that show excess MUC16 in the tear film of SS subjects, allowed us to speculate on the possible mechanisms of such mucin production.
Spec (possible) Regulation (speculate) of Gene_expression (production) of mucin in tear associated with syndrome
5) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.69 Pain Relevance 0
Although alterations in mucin expression and/or mucin glycosylation have been implicated in the pathophysiology of dry eye, only a limited number of studies addressing these issues have been conducted.
Regulation (alterations) of Gene_expression (expression) of mucin in eye associated with dry eye
6) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.69 Pain Relevance 0
These significant changes in MUC1 expression may represent compensatory or protective responses to chronic insult to the ocular surface.



Regulation (changes) of Gene_expression (expression) of MUC1
7) Confidence 0.27 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927371 Disease Relevance 1.25 Pain Relevance 0
MMP9 mRNA expression correlated with PDGFA mRNA up to POD 14 (p = 0.007) and treatment with sivelestat altered MUC1 expression (p = 0.024, Figure 2b).
Regulation (altered) of Gene_expression (expression) of MUC1
8) Confidence 0.25 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.24 Pain Relevance 0.13
Although alterations in mucin expression and/or mucin glycosylation have been implicated in the pathophysiology of dry eye, only a limited number of studies addressing these issues have been conducted.
Regulation (alterations) of Gene_expression (expression) of mucin in eye associated with dry eye
9) Confidence 0.23 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.70 Pain Relevance 0
The overview will point out the present knowledge about changes in the mucin gene expression in pancreatic intraepithelial neoplasia (PanINs) as precursor lesions and in pancreatic adenocarcinoma, compared to normal pancreas and chronic pancreatitis and the potential role for differentiating chronic pancreatitis from pancreatic cancer.
Regulation (changes) of Gene_expression (expression) of mucin gene in pancreas associated with adenocarcinoma, cancer, pancreatic cancer and chronic pancreatitis
10) Confidence 0.23 Published 2003 Journal Mol Cancer Section Abstract Doc Link PMC149423 Disease Relevance 1.27 Pain Relevance 0.26

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