INT17306

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Context Info
Confidence 0.11
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.37
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cell line cells 1
T-cells 1
RT1-CE1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 8 99.90 Very High Very High Very High
Root ganglion neuron 2 99.68 Very High Very High Very High
agonist 20 87.36 High High
Pain 20 60.80 Quite High
Osteoarthritis 112 51.28 Quite High
antagonist 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 8 99.90 Very High Very High Very High
Ganglion Cysts 2 99.36 Very High Very High Very High
Weight Gain 8 90.76 High High
Disease 6 74.08 Quite High
Hypertrophy 24 72.24 Quite High
Pain 16 60.80 Quite High
Osteoarthritis 110 51.28 Quite High
Fatigue 4 19.44 Low Low
Frailty 8 5.00 Very Low Very Low Very Low
Muscle Weakness 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophoretic analysis of MHC isoforms demonstrated that clenbuterol pre-treatment prior to MNX suppressed the increase in MHC I protein, which was previously associated with MNX surgery, and numerically, maintained the MHC IIB complement (Table II).
Positive_regulation (increase) of MHC I protein
1) Confidence 0.11 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.29 Pain Relevance 0.10
Although we only noted a trend association between pre-treatment with clenbuterol and suppression of the increase in MHC I protein observed post surgery (P = 0.081), this is supported by several studies that report the slow to fast fibre inducing effects of clenbuterol in rodents44.
Positive_regulation (increase) of MHC I protein
2) Confidence 0.11 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.18 Pain Relevance 0.11
MHC class I and II molecules were induced on Scs using recombinant murine interferon-gamma (IFN-gamma), lymph node cells (LNC), removed at day 9 from Lewis rats with experimental allergic neuritis (EAN) and syngeneic T-cell line cells responsive to P2 basic protein.
Positive_regulation (induced) of MHC class I in cell line cells associated with experimental autoimmune neuritis and neuritis
3) Confidence 0.09 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1899426 Disease Relevance 0.45 Pain Relevance 0.39
EAN LNC induced MHC class I on Scs but only IFN-gamma or P2-responsive T-cells induced MHC class II.
Positive_regulation (induced) of MHC class I in T-cells associated with neuritis
4) Confidence 0.07 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1899426 Disease Relevance 0.46 Pain Relevance 0.41

General Comments

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