INT173085

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Context Info
Confidence 0.08
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LILRA3) extracellular region (LILRA3) plasma membrane (LILRA3)
LILRA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 1 91.60 High High
Inflammation 18 83.28 Quite High
Kinase C 1 67.84 Quite High
agonist 20 60.64 Quite High
Glutamate receptor 2 56.28 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Tumor 1 92.28 High High
Cancer 127 90.36 High High
Carcinoma 1 88.68 High High
INFLAMMATION 21 83.28 Quite High
Coronary Heart Disease 1 78.88 Quite High
Hypoxia 51 75.88 Quite High
Ovarian Cancer 1 28.04 Quite Low
Pancreatic Cancer 81 27.20 Quite Low
Disease 6 24.48 Low Low
Syndrome 2 10.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the VHL protein is a subunit in the multimeric E3 ubiquitin ligase complex, its binding to the ODD regions of HIF-1?
E3 Binding (binding) of
1) Confidence 0.08 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.61 Pain Relevance 0.05
recognized by the E3-?
E3 Binding (recognized) of
2) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.27 Pain Relevance 0.19
E3 ubiquitin ligases, hundreds of which exist in mammalian genomes, appear to recognize specific proteins and thus determine the specificity of protein substrates targeted for UPS-mediated degradation [9].
E3 Binding (recognize) of
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0.03

General Comments

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