INT173088

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Context Info
Confidence 0.29
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (BAI1) cell adhesion (BAI1) plasma membrane (BAI1)
signal transducer activity (BAI1)
Anatomy Link Frequency
lymphocytes 1
brain 1
BAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 49 5.00 Very Low Very Low Very Low
imagery 27 5.00 Very Low Very Low Very Low
Central nervous system 22 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Solid Tumor 9 100.00 Very High Very High Very High
Cancer 279 99.84 Very High Very High Very High
Cold Sores 367 97.42 Very High Very High Very High
Metastasis 35 90.28 High High
Pancreatic Cancer 82 87.84 High High
Disease 37 77.36 Quite High
Colon Cancer 4 76.96 Quite High
Sprains And Strains 11 72.24 Quite High
Stress 2 71.76 Quite High
Hypoxia 50 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been recently demonstrated in an in vivo model that an oncolytic HSV-1, named RAMBO (Rapid Antiangiogenesis Mediated By Oncolytic virus), that can express vasculostatin (Vstat120), the cleaved and secreted extracellular fragment of brain-specific angiogenesis inhibitor 1 (BAI1), under the control of IE4/5 promoter, displays an anti-tumour effect upon delivery into established tumours.
Localization (secreted) of BAI1 in brain associated with cold sores and cancer
1) Confidence 0.29 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.42 Pain Relevance 0
Since this first description of angiogenesis as a requisite process for continuous solid tumor growth, many endogenous pro- and anti-angiogenic substances secreted by tumor cells, tissue resident and stromal cells, and infiltrating lymphocytes have been characterized [3-7].
Localization (secreted) of angiogenesis in lymphocytes associated with cancer and solid tumor
2) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.29 Pain Relevance 0

General Comments

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