INT173089

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.09
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.48
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VHLL)
Anatomy Link Frequency
central nervous system 1
VHLL (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 96.72 Very High Very High Very High
cytokine 22 5.00 Very Low Very Low Very Low
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 173 100.00 Very High Very High Very High
Von Hippel-lindau Syndrome 9 100.00 Very High Very High Very High
Carcinoma 2 99.16 Very High Very High Very High
Renal Cancer 43 99.02 Very High Very High Very High
Brain Tumor 2 95.80 Very High Very High Very High
Hypoxia 102 90.72 High High
Syndrome 5 84.80 Quite High
Genomic Instability 2 64.48 Quite High
Immunotherapy Of Cancer 1 42.68 Quite Low
Pancreatic Cancer 162 39.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, loss of the VHL protein results in constitutive stabilization of HIF-1?
Negative_regulation (loss) of VHL protein
1) Confidence 0.09 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.60 Pain Relevance 0.04
The von Hippel-Lindau protein (pVHL) is the product of the VHL gene, a tumor-suppressor gene known to be inactivated in renal clear-cell carcinomas as well as other markedly vascular tumors such as central nervous system hemangioblastoma [24].
Negative_regulation (inactivated) of VHL gene in central nervous system associated with cancer, carcinoma, central nervous system and brain tumor
2) Confidence 0.06 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.62 Pain Relevance 0.05
A further critical breakthrough came with the recognition that the majority of ordinary sporadic renal cancers of the clear cell type are also associated with loss or dysfunction of both VHL gene copies (Na et al 2003), and therefore that clear cell renal cancer might be especially vulnerable to anti-angiogenic therapy.
Negative_regulation (loss) of VHL gene associated with von hippel-lindau syndrome and renal cancer
3) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727778 Disease Relevance 1.26 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox