INT173090

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 9.45
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
plasma 1
smooth muscle 1
muscle 1
brain 1
bone marrow 1
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 199 99.28 Very High Very High Very High
diclofenac 46 99.08 Very High Very High Very High
alcohol 21 98.64 Very High Very High Very High
Hippocampus 19 97.08 Very High Very High Very High
antiepileptic Drug 27 95.88 Very High Very High Very High
ischemia 27 95.44 Very High Very High Very High
Central nervous system 97 95.24 Very High Very High Very High
Pain 15 94.92 High High
Osteoarthritis 54 94.72 High High
cytokine 118 81.84 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 96 100.00 Very High Very High Very High
Diabetes Mellitus 400 99.84 Very High Very High Very High
Stroke 30 99.36 Very High Very High Very High
INFLAMMATION 205 99.28 Very High Very High Very High
Toxicity 212 98.88 Very High Very High Very High
African Trypanosomiasis 46 98.40 Very High Very High Very High
Shock 6 98.36 Very High Very High Very High
Epilepsy 10 97.60 Very High Very High Very High
Hypercalcemia 1 97.16 Very High Very High Very High
Cv Unclassified Under Development 19 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of this study was to determine in vitro the effect of the admixture of vitamin A with a clinically relevant surfactant preparation on miscibility and surface tension properties.


Spec (determine) Regulation (effect) of in vitro
1) Confidence 0.09 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761185 Disease Relevance 0.15 Pain Relevance 0.04
SELECTING THE IN VITRO TEST SYSTEM
Regulation (SELECTING) of IN VITRO
2) Confidence 0.04 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.73 Pain Relevance 0
The search looked for prospective randomized and nonrandomized controlled studies; prospective nonrandomized uncontrolled studies; retrospective studies; case reports; and in vitro studies.
Regulation (looked) of in vitro
3) Confidence 0.04 Published 2010 Journal Nutr J Section Body Doc Link PMC3022641 Disease Relevance 0.15 Pain Relevance 0.09
However, evidence of distinct binding proteins that modulate processing of pri-miRNA to mature miRNA [92] has emerged and we clearly demonstrate that expression of miR-1 and miR-133a are not co-regulated in vivo in human skeletal muscle.
Regulation (regulated) of in vivo in skeletal muscle
4) Confidence 0.03 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.33 Pain Relevance 0
Several miRNAs are highly regulated in vivo and in vitro during muscle development and these regulate the muscle differential expression process [55].
Regulation (regulated) of in vivo in muscle
5) Confidence 0.03 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.55 Pain Relevance 0
In vivo, enzyme activity is highly regulated at a number of different levels (for example, gene expression and translation, proenzyme activation, enzyme-matrix interactions, endogenous inhibitors, and so on [17]).
Regulation (regulated) of In vivo
6) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.03
An in vivo study has been conducted on 47 healthy women and men in order to investigate whether daily intake of powdered propolis extract during 30 days has any influence on antioxidative status based on the following blood parameters: activity of superoxide dismutase, glutathione peroxidase and catalase, concentration of plasma malondialdehyde, total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose, uric acid, ferritin and transferrin, together with routine red blood cell parameters.
Regulation (conducted) of in vivo in blood associated with disorder of lipid metabolism
7) Confidence 0.03 Published 2009 Journal Nutr J Section Body Doc Link PMC2732638 Disease Relevance 0.09 Pain Relevance 0
Nevertheless, it cannot be excluded that factors present in conditioned serum, either known or as yet undiscovered, play a role in vivo by inducing other mediators, not determined in the current study, in the joint space.
Regulation (role) of in vivo in joint
8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.64 Pain Relevance 0.29
We have shown that FePro labeling does not alter the in vitro differentiation capacity of CD34 positive hematopoietic stem cells (HSCs) or bone marrow stromal cells (BMSC) to osteogenic or adipogenic cells [9], [10].
Neg (not) Regulation (alter) of in vitro in bone marrow
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2898800 Disease Relevance 0 Pain Relevance 0.04
Detection of miRNA-133a target protein in vitro and in vivo
Regulation (Detection) of in vivo
10) Confidence 0.02 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.06 Pain Relevance 0.03
Interestingly, our new analysis procedure subsequently identified CDC42 and PTBP1 as being equally targeted by both up- and down-regulated miRNAs (Additional file 2); thus, CDC42 and PTBP1 should not be altered in vivo by diabetes (as we demonstrated by western blotting prior to developing our ranking metric).


Neg (not) Regulation (altered) of in vivo associated with diabetes mellitus
11) Confidence 0.02 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.28 Pain Relevance 0
In contrast, analysis of CDC42 and PTBP1 proteins in muscle tissue provided no evidence that these targets were altered in vivo (n = 7 to 8 subjects per group; Figure S4D in Additional file 1).
Regulation (altered) of in vivo in muscle tissue
12) Confidence 0.02 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
On the other hand employment of any one of the preservatives likes sorbic acid, benzyl alcohol, thiomersal and phenylmercuric acetate has been found to adversely affect the in vitro corneal permeation of diclofenac (10).
Regulation (affect) of in vitro associated with diclofenac and alcohol
13) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2751374 Disease Relevance 0.07 Pain Relevance 0.56
Interestingly, despite evidence for the presence of VEGF receptor expression in one of the cell lines used (AsPC-1), the inhibitory effects of the fusion protein were isolated anti-angiogenic phenomena, as the doses of the protein showed no effect on cell growth in vitro [89].
Neg (no) Regulation (effect) of in vitro in AsPC-1
14) Confidence 0.02 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.99 Pain Relevance 0.04
Preclinical data have reported that these peptides have potent antiviral activity and durable control of HIV replication in vitro (Delmedico et al. 2006).


Regulation (control) of in vitro associated with acquired immune deficiency syndrome or hiv infection
15) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012555 Disease Relevance 0.74 Pain Relevance 0.06
In another study, we found sets of genes from SEB exposures in vitro also were predictive of in vivo responses in a piglet model of SEB-induced lethal shock [12].
Regulation (responses) of in vivo associated with shock
16) Confidence 0.01 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2542375 Disease Relevance 0.18 Pain Relevance 0
In vitro the osteoclast differenciation is dramatically affected both in DAP12-deficient PLOSL patients and DAP12-deficient mice [15], [16], [17], [18].
Regulation (affected) of In vitro in osteoclast
17) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.78 Pain Relevance 0.21
Fexinidazole is orally available and rapidly metabolized in two metabolites having equivalent biological activity to the parent and contributing significantly to the in vivo efficacy in animal models of both stage 1 and 2 HAT.
Regulation (efficacy) of in vivo in stage 1 associated with african trypanosomiasis
18) Confidence 0.00 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3006138 Disease Relevance 0.33 Pain Relevance 0
We also show that (S)-roscovitine regulates CDK5 in vivo activity after stroke, suggesting that CDK5 is involved in (S)-roscovitine in vivo beneficial effect on ischemic brain.


Regulation (regulates) of in vivo in brain associated with stroke
19) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.92 Pain Relevance 0.15
The smooth muscle experiments (Figure 1), those on sheep airway function (Figure 7), as well as in the data concerning horses with heaves described in the text, demonstrate that ascorbate has absolutely no measurable effect on uncontracted, ACh-contracted, or carbachol-contracted airway smooth muscle in vitro or on lung function in vivo in four different animal species.
Neg (no) Regulation (effect) of in vivo in smooth muscle
20) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0.16 Pain Relevance 0.16

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