INT173095

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.83
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
Anatomy Link Frequency
epithelial cells 2
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 98.18 Very High Very High Very High
Chronic pancreatitis 3 97.40 Very High Very High Very High
imagery 61 93.84 High High
Inflammation 6 64.08 Quite High
addiction 4 62.52 Quite High
opiate 1 15.88 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 74 99.84 Very High Very High Very High
Pancreatitis 3 97.40 Very High Very High Very High
Reprotox - General 1 2 97.00 Very High Very High Very High
Cancer 215 86.32 High High
Disease 21 85.60 High High
Renal Cancer 55 84.12 Quite High
Pancreatic Cancer 81 83.84 Quite High
Severe Combined Immunodeficiency 1 83.52 Quite High
Hematologic Neoplasms 1 80.88 Quite High
Adenocarcinoma 12 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it has been shown that elevated SMRT levels result in suppression of target genes for the vitamin D receptor (VDR) in prostate cancer cells and in apparent hormonal insensitivity (Khanim et al. 2004).
Positive_regulation (elevated) of Gene_expression (levels) of SMRT associated with reprotox - general 1
1) Confidence 0.39 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.16 Pain Relevance 0.03
These results were later reinforced by von Marschall et al, who demonstrated overexpression of VEGF and VEGF receptors in cancerous ductal epithelial cells versus normal pancreas and chronic pancreatitis specimens using immunohistochemistry and in-situ hybridization [83].
Positive_regulation (overexpression) of Gene_expression (overexpression) of receptors in epithelial cells associated with chronic pancreatitis
2) Confidence 0.03 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.63 Pain Relevance 0.10
Several other ligands are being evaluated for the molecular characterization of breast cancer: among many others, these include ligands for assessing the HER2/neu status of breast cancers [111], radiolabeled metalloproteinase inhibitors to measure invasion capacity [112] and labeled peptides to detect cell surface receptors that are overexpressed in breast cancer cells [113].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of receptors associated with breast cancer and metalloproteinase
3) Confidence 0.00 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175073 Disease Relevance 1.04 Pain Relevance 0.26

General Comments

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