INT1731

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.31
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
plasma 1
nerve 1
vagal nerve 1
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
Opioid 3 99.20 Very High Very High Very High
dexamethasone 8 98.12 Very High Very High Very High
antagonist 3 94.88 High High
Clonidine 2 94.68 High High
tetrodotoxin 3 83.28 Quite High
Angina 1 83.28 Quite High
Serotonin 2 75.00 Quite High
Dopamine 2 61.00 Quite High
Enkephalin 4 57.60 Quite High
Disease Link Frequency Relevance Heat
Hypertension 1 84.64 Quite High
Cv General 3 Under Development 1 83.28 Quite High
Myocardial Infarction 1 78.16 Quite High
Natriuresis 1 62.88 Quite High
Bordatella Infection 1 41.04 Quite Low
Decapitation 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid peptide receptor (OPR) agonists are co-released with the beta-adrenergic receptor (beta-AR) agonist norepinephrine (NE) from nerve terminals in the heart during sympathetic stimulation.
Localization (released) of beta-AR in nerve associated with agonist and opioid
1) Confidence 0.43 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124441 Disease Relevance 0 Pain Relevance 0.47
These results not only confirm a beta-adrenoceptor mediated release of 5-HT, but also suggest that other mechanisms are involved in the total response to vagal nerve stimulation.
Localization (release) of beta-adrenoceptor in vagal nerve
2) Confidence 0.38 Published 1979 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 229694 Disease Relevance 0 Pain Relevance 0.14
Tazolol (10(-8) to 10(-7) M), beta-1-agonist, and salbutamol (10(-10) to 10(-8) M), beta-2-agonist, dose-dependently increased impulse-evoked release.
Localization (release) of beta-1-agonist associated with agonist
3) Confidence 0.35 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982014 Disease Relevance 0 Pain Relevance 0.31
Metoprolol CR/ZOK (controlled release, zero order kinetics) is a new formulation of an extensively used beta 1-selective, beta-adrenoceptor blocking drug, (beta 1-blocker), designed to provide continuous, even, plasma concentrations in the therapeutic range.
Localization (release) of beta-adrenoceptor in plasma
4) Confidence 0.17 Published 1989 Journal J Clin Pharm Ther Section Abstract Doc Link 2668307 Disease Relevance 0.25 Pain Relevance 0.08
In contrast, isoprenaline, a beta-AR agonist which was ineffective when applied alone, enhanced irANP secretion from hypothalamic cultures in the presence of DM.
Localization (secretion) of beta-AR associated with agonist and dexamethasone
5) Confidence 0.12 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0.06 Pain Relevance 0.66

General Comments

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