INT173102

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.34
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VHLL)
VHLL (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 98.88 Very High Very High Very High
cytokine 24 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Von Hippel-lindau Syndrome 9 100.00 Very High Very High Very High
Brain Tumor 3 99.56 Very High Very High Very High
Hypoxia 120 99.36 Very High Very High Very High
Cancer 279 97.64 Very High Very High Very High
Carcinoma 3 95.96 Very High Very High Very High
Syndrome 5 93.00 High High
Renal Cancer 44 91.44 High High
Immunotherapy Of Cancer 1 80.96 Quite High
Solid Tumor 15 76.48 Quite High
Stress 4 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the VHL protein is a subunit in the multimeric E3 ubiquitin ligase complex, its binding to the ODD regions of HIF-1?
VHL protein Binding (subunit) of
1) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.57 Pain Relevance 0.05
The VHL protein contains a binding site in the oxygen-dependent degradation domain (ODD) of HIF-1?
VHL protein Binding (binding) of
2) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.59 Pain Relevance 0.05
In well-oxygenated conditions, the VHL gene product pVHL recognizes HIF1?
VHL gene Binding (recognizes) of associated with von hippel-lindau syndrome
3) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727778 Disease Relevance 1.39 Pain Relevance 0
This interaction, and through binding of elongin C via von Hippel-Lindau ?
Hippel-Lindau Binding (interaction) of
4) Confidence 0.02 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.79 Pain Relevance 0

General Comments

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