INT173105

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.47
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 20 95.04 Very High Very High Very High
agonist 1 89.08 High High
Dopamine 1 88.76 High High
antagonist 29 79.12 Quite High
Inflammation 26 76.28 Quite High
Central nervous system 2 64.16 Quite High
imagery 8 29.88 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
Serotonin 10 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 106 99.88 Very High Very High Very High
Toxoplasmosis 1 99.54 Very High Very High Very High
Cancer 192 96.88 Very High Very High Very High
Ovarian Cancer 23 95.04 Very High Very High Very High
American Trypanosomiasis 1 93.68 High High
Pulmonary Hypertension 170 89.60 High High
Apoptosis 31 84.48 Quite High
Increased Venous Pressure Under Development 2 83.72 Quite High
Death 5 80.96 Quite High
Infection 91 77.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies revealed that Toxoplasma infection rapidly increased the abundance of the HIF1?
Transcription (abundance) of HIF associated with toxoplasmosis
1) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.82 Pain Relevance 0.04
An increase in the protein level of HIF-1?
Transcription (level) of HIF
2) Confidence 0.67 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.69 Pain Relevance 0.14
to form the HIF-1 complex, and activation of transcription through HIF-1's binding to specific HREs in target sequences (see Figure 2).
Transcription (transcription) of HIF-1
3) Confidence 0.36 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.59 Pain Relevance 0.03
protein levels increase in the cells, the HIF-1 transcription complex is formed and binds to the HRE binding site.
Transcription (transcription) of HIF-1
4) Confidence 0.12 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.98 Pain Relevance 0.07
Under hypoxia PHD2 activity is decreased and HIF-1?
Transcription (activity) of HIF-1 associated with hypoxia
5) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.94 Pain Relevance 0
Although we did not identify these genes in this SSH screen, we found the key oxygen sensor, PHD2, which regulates the HIF-1 transcription complex, that subsequently regulates VEGF expression and we found a kinase, SNRK, that regulates a second kinase, LKB1, that is a component of the VEGF signalling pathway.
Transcription (transcription) of HIF-1
6) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.46 Pain Relevance 0

General Comments

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