INT173112

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, VCAM1) aging (IL1B, VCAM1) cytosol (IL1B)
signal transduction (IL1B) extracellular region (IL1B) cell adhesion (VCAM1)
Anatomy Link Frequency
endothelial cells 4
IL1B (Homo sapiens)
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 98.04 Very High Very High Very High
Inflammation 40 85.12 High High
rheumatoid arthritis 121 83.20 Quite High
antagonist 1 76.28 Quite High
Infliximab 5 72.64 Quite High
Etanercept 1 69.12 Quite High
Pain 2 59.84 Quite High
chemokine 31 56.56 Quite High
Arthritis 10 46.84 Quite Low
methotrexate 1 45.92 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 1 92.24 High High
Adhesions 54 90.40 High High
INFLAMMATION 40 85.12 High High
Adult Respiratory Distress Syndrome 67 84.00 Quite High
Rheumatoid Arthritis 121 83.20 Quite High
Critical Illness 1 77.92 Quite High
Pain 2 59.84 Quite High
Apoptosis 5 50.00 Quite Low
Arthritis 10 46.84 Quite Low
Lung Injury 2 46.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that endothelial cell activation and VCAM-1 expression is induced mainly by IL-1b and TNF-?.
IL-1b Positive_regulation (induced) of Gene_expression (expression) of VCAM-1 in endothelial cell
1) Confidence 0.43 Published 2002 Journal Respir Res Section Body Doc Link PMC150513 Disease Relevance 0.77 Pain Relevance 0.14
In addition, IL-1 and TNF upregulate the expression of ICAM-1, VCAM-1 and E-selectin on endothelial cells, stimulating leukocyte migration into the joint [76,104].
IL-1 Positive_regulation (upregulate) of Gene_expression (expression) of VCAM in endothelial cells
2) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.57 Pain Relevance 0.62

General Comments

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