INT173114

Context Info Confidence 0.49 First Reported 2002 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 2.56 Pain Relevance 1.22

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B) aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)

Anatomy Link Frequency lung 2 IL1B (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 92 99.82 Nerve growth factor 54 95.64 Inflammation 95 94.84 substance P 13 94.80 chemokine 5 94.28 agonist 24 90.16 Pain 32 86.64 Neuropeptide 10 85.60 Arthritis 13 73.40 antagonist 16 73.28

Disease Link Frequency Relevance Heat Lung Injury 2 99.74 Immunization 1 97.04 INFLAMMATION 101 94.84 Mycobacterial Infection 19 93.32 Nociception 6 92.40 Pain 27 86.64 Critical Illness 1 83.76 Chondrosarcoma 6 83.68 Adhesions 26 77.28 Disease 75 77.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previously, we determined that simultaneous treatment with IL-1?

Spec (determined) Positive_regulation (simultaneous) of IL-1 Spec (determined) Binding (treatment) of

1) Confidence 0.49 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.23 Pain Relevance 0.12

The severity of lung injury seems to be related negatively with BALF IL-1, TNF-?

Positive_regulation (negatively) of BALF IL-1 Binding (related) of in lung associated with lung injury

2) Confidence 0.32 Published 2002 Journal Respir Res Section Body Doc Link PMC150513 Disease Relevance 0.53 Pain Relevance 0.15

The antibody was initially identified from a hybridoma derived from these mice because of its ability to bind human IL-1?

Positive_regulation (derived) of IL-1 Binding (bind) of

3) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0.10 Pain Relevance 0.10

A report indicates that sIL-1RAcP associates as ligand-bound to type II sIL-1R, increasing the binding affinity of IL-1?

Positive_regulation (increasing) of IL-1 Binding (affinity) of

4) Confidence 0.10 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.25 Pain Relevance 0.07

on neurotrophin expression in the IVD also requires the presence of IL-1?

Positive_regulation (requires) of IL-1 Binding (presence) of

5) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.50 Pain Relevance 0.47

Cytokines such as IL-1 can also stimulate the NFkB binding molecule to activate NFkB [54-56], which induces the expression of cyclooxygenase-2 (COX-2), which consequently leads to tissue inflammation at the site where latent TB antigens are located.

Positive_regulation (stimulate) of IL-1 Binding (binding) of associated with mycobacterial infection, inflammation and cytokine

6) Confidence 0.09 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.87 Pain Relevance 0.23

secretion, without the loss of membrane asymmetry, whereas a subsequent hit with ATP drives a rapid amplification of IL-1?

Positive_regulation (drives) of IL-1 Binding (amplification) of

7) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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