INT173116

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.85
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
leukocyte 2
chondrocytes 1
fibroblast 1
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 282 100.00 Very High Very High Very High
Inflammatory marker 13 100.00 Very High Very High Very High
chemokine 8 100.00 Very High Very High Very High
antagonist 3 100.00 Very High Very High Very High
diclofenac 53 99.56 Very High Very High Very High
Osteoarthritis 67 98.72 Very High Very High Very High
dexamethasone 7 97.56 Very High Very High Very High
cytokine 78 94.72 High High
agonist 17 85.92 High High
tolerance 7 81.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 337 100.00 Very High Very High Very High
Adhesions 283 100.00 Very High Very High Very High
Nicotine Addiction 368 99.80 Very High Very High Very High
Focal Cartilage Defect 56 99.64 Very High Very High Very High
Apoptosis 26 98.80 Very High Very High Very High
Osteoarthritis 80 98.72 Very High Very High Very High
Syndrome 3 98.24 Very High Very High Very High
Atherosclerosis 54 97.96 Very High Very High Very High
Recurrence 19 96.56 Very High Very High Very High
Metastasis 16 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BALF soluble adhesion molecules sICAM and sVCAM did not differ among the three groups of patients.
Neg (not) Regulation (differ) of sVCAM associated with adhesions
1) Confidence 0.33 Published 2002 Journal Respir Res Section Body Doc Link PMC150513 Disease Relevance 0.83 Pain Relevance 0.15
Elsewhere, much of the available evidence suggests that tobacco smoking does not influence sVCAM-1 concentrations [134,142,223].
Neg (not) Regulation (influence) of sVCAM-1 associated with nicotine addiction
2) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.56 Pain Relevance 0.03
Elsewhere, much of the available evidence suggests that tobacco smoking does not influence sVCAM-1 concentrations [134,142,223].
Regulation (influence) of sVCAM-1 associated with nicotine addiction
3) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.56 Pain Relevance 0.03
Three additional genes, vascular cell adhesion molecule-1 (VCAM-1), chitinase 3-like 2 (CHI3L2) and the chemokine CXCL12 were down-regulated in sheared chondrocytes, although these genes have been reported to be up-regulated in the microarray profiling of OA chondrocytes [15], [22], [23].


Regulation (regulated) of vascular cell adhesion molecule-1 in chondrocytes associated with chemokine, osteoarthritis and adhesions
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.93 Pain Relevance 0.42
In this research, human synovial MSCs attached to the cartilage defect 10 minutes after plating already expressed ICAM-1 and VCAM-1, and neutralizing antibodies for ICAM-1, VCAM-1, or activated leukocyte-cell adhesion molecule inhibited the attachment.
Regulation (plating) of VCAM-1 in leukocyte associated with focal cartilage defect and adhesions
5) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575632 Disease Relevance 0.60 Pain Relevance 0
Diclofenac intervention did not affect levels of the known inflammation markers CRP, sialic acid, VCAM or ICAM.
Neg (not) Regulation (affect) of VCAM associated with inflammation and diclofenac
6) Confidence 0.22 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.50 Pain Relevance 0.34
Cell adhesion molecules such as E-selectin, ICAM-1, and VCAM-1, are regulated by NF-?
Regulation (regulated) of VCAM-1 associated with adhesions
7) Confidence 0.22 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234426 Disease Relevance 0.97 Pain Relevance 0
B target genes VCAM-1 and COX-2 are also
Regulation (target) of VCAM-1
8) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.32 Pain Relevance 0.26
They as O'Brien found that E-Selectin, ICAM and VCAM were up regulated.
Regulation (regulated) of VCAM
9) Confidence 0.15 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.02 Pain Relevance 0.12
, IL6, IL18, IL10, E-selectin, intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) was not associated with response to anti-TNF?
Neg (not) Regulation (ot associa) of vascular cell adhesion molecule in fibroblast associated with adhesions
10) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2564801 Disease Relevance 0.60 Pain Relevance 0.16
In this research, human synovial MSCs attached to the cartilage defect 10 minutes after plating already expressed ICAM-1 and VCAM-1, and neutralizing antibodies for ICAM-1, VCAM-1, or activated leukocyte-cell adhesion molecule inhibited the attachment.
Regulation (antibodies) of VCAM-1 in leukocyte associated with focal cartilage defect and adhesions
11) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575632 Disease Relevance 0.55 Pain Relevance 0
Although fewer studies have been performed, the results have been mixed with respect to the effect of ALA on inflammatory markers such as C-reactive protein, vascular cellular adhesion molecule-1, E-selectin, and interleukin-6.
Regulation (effect) of vascular cellular adhesion molecule-1 associated with inflammatory marker and adhesions
12) Confidence 0.10 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.86 Pain Relevance 0.09
Recent reports have shown the inhibitory effects of statins on adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule (VCAM-1) and E-selectin, which are involved in the adhesion, rolling, extravasation of inflammatory cells.
Regulation (effects) of vascular cell adhesion molecule associated with inflammation and adhesions
13) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2858830 Disease Relevance 1.24 Pain Relevance 0.21
There was no significant effect of treatment on soluble TNF receptors, IL-1 receptor antagonist or sVCAM1 (which increased slightly; table 4).
Neg (no) Regulation (effect) of sVCAM1 associated with antagonist
14) Confidence 0.03 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1501038 Disease Relevance 0.31 Pain Relevance 0.10

General Comments

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