INT17312

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Context Info
Confidence 0.41
First Reported 1991
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 30
Total Number 37
Disease Relevance 33.01
Pain Relevance 4.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HSPG2) small molecule metabolic process (HSPG2) extracellular region (HSPG2)
plasma membrane (HSPG2) extracellular matrix organization (HSPG2) lipid metabolic process (HSPG2)
Anatomy Link Frequency
skin 4
cranial 2
synapse 2
blood 1
leukocyte 1
HSPG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 60 99.98 Very High Very High Very High
corticosteroid 57 99.90 Very High Very High Very High
Inflammation 28 99.86 Very High Very High Very High
carbamazepine 111 99.80 Very High Very High Very High
withdrawal 24 99.80 Very High Very High Very High
anticonvulsant 26 99.20 Very High Very High Very High
Lamotrigine 45 99.08 Very High Very High Very High
Ventral tegmentum 4 97.64 Very High Very High Very High
agonist 171 96.96 Very High Very High Very High
headache 2 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Staphylococcus Infection 1149 100.00 Very High Very High Very High
Bullous Skin Disease 784 100.00 Very High Very High Very High
Syndrome 634 100.00 Very High Very High Very High
Genetic Predisposition To Disease 14 100.00 Very High Very High Very High
Skin Infection 7 100.00 Very High Very High Very High
INFLAMMATION 45 99.86 Very High Very High Very High
Infection 30 99.64 Very High Very High Very High
Exanthema 21 99.44 Very High Very High Very High
Disease 162 98.88 Very High Very High Very High
Drug Hypersensitivity 30 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because coincidence cannot be excluded from the assessments of the degree and rate of improvement for the few patients treated with corticosteroid, from the low frequency of complications, and from the mortality rate of zero in this series of patients, the use of corticosteroids for SJS associated with MP infection is questionable.
SJS Binding (associated) of associated with corticosteroid, syndrome and infection
1) Confidence 0.41 Published 1991 Journal Clin Pediatr (Phila) Section Abstract Doc Link 1899814 Disease Relevance 1.64 Pain Relevance 0.16
With increasing evidence that phenytoin and levetiracetam are equally efficacious for seizure treatment and prophylaxis, and since there is no link identified so far of an association between levetiracetam and SJS, we believe that levetiracetam is a better option for patients who need anticonvulsant medication(s) while undergoing radiation therapy, especially cranial irradiation.
SJS Neg (no) Binding (association) of in cranial associated with convulsion, syndrome and anticonvulsant
2) Confidence 0.41 Published 2010 Journal Radiat Oncol Section Abstract Doc Link 20525360 Disease Relevance 1.06 Pain Relevance 0.12
SJS/TEN is characterized by a macular exanthema ('atypical targets') which focusses on the face, neck, and the central trunk regions.
SJS Binding (characterized) of in trunk regions associated with exanthema
3) Confidence 0.36 Published 2000 Journal Am J Clin Dermatol Section Abstract Doc Link 11702611 Disease Relevance 0.72 Pain Relevance 0.18
Using a behavioral sensitization paradigm, we demonstrate that microinjections of PLC gamma 1 into distinct (rostral vs. caudal) regions of the VTA result in differential locomotor responses to morphine.
PLC Binding (microinjections) of associated with ventral tegmentum and morphine
4) Confidence 0.36 Published 2005 Journal Synapse Section Abstract Doc Link 15765533 Disease Relevance 0.09 Pain Relevance 0.53
Furthermore, in Schwartz-Jampel syndrome type 1, it is true that it is phenotypically similar but genetically it is a distinct disorder caused by mutation in the HSPG2 gene on chromosome 1p36.1-p34.
HSPG2 gene Binding (mutation) of associated with syndrome
5) Confidence 0.34 Published 2008 Journal Cases J Section Body Doc Link PMC2533000 Disease Relevance 1.30 Pain Relevance 0
So, we encourage injection of autologous blood to the SJS and PT for treatment of patients with chronic recurrent TMJ dislocation, as it has shown better clinical and radiographic results than its injection only to the SJS.


SJS Binding (injection) of in blood
6) Confidence 0.32 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19926503 Disease Relevance 0 Pain Relevance 0
SJS is very rarely associated with tetracyclines.
SJS Binding (associated) of associated with syndrome
7) Confidence 0.31 Published 2007 Journal Cutis Section Abstract Doc Link 17388211 Disease Relevance 0.72 Pain Relevance 0.25
With increasing evidence that phenytoin and levetiracetam are equally efficacious for seizure treatment and prophylaxis, and since there is no link identified so far of an association between levetiracetam and SJS, we believe that levetiracetam is a better option for patients who need anticonvulsant medication(s) while undergoing radiation therapy, especially cranial irradiation.



SJS Neg (no) Binding (association) of in cranial associated with convulsion, syndrome and anticonvulsant
8) Confidence 0.31 Published 2010 Journal Radiat Oncol Section Abstract Doc Link PMC2894848 Disease Relevance 1.06 Pain Relevance 0.12
While types 1A and 1B are caused by mutations in Perlecan at 1p36.1, type 2 shows no linkage to the SJS locus on chromosome 1. [7] Type 2 is now identified as Stüve-Wiedemann syndrome, a genetically distinct, and highly lethal disorder. [4]
SJS Neg (no) Binding (linkage) of associated with syndrome
9) Confidence 0.31 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 1.21 Pain Relevance 0.07
Peng et al. (1999) demonstrated that perlecan in vitro binds to acetylcholinesterase, and postulated that the perlecan-dystroglycan complex may function as an acceptor molecule for acetylcholinesterase at the neuromuscular junction. [9] Arikawa-Hirasawa et al. (2002) have shown that in perlecan-null mice, agrin and acetylcholine molecules were present at the neuromuscular junction but acetylcholinesterase was totally absent, indicating that perlecan binds acetylcholinesterase and localizes it at the synapse. [10]
perlecan Binding (binds) of in synapse
10) Confidence 0.31 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 0.44 Pain Relevance 0.04
Prompt recognition of SJS and withdrawal of the offending medication is key to treating this disorder.
SJS Binding (recognition) of associated with syndrome and withdrawal
11) Confidence 0.31 Published 2001 Journal Clin J Oncol Nurs Section Abstract Doc Link 11899397 Disease Relevance 0.91 Pain Relevance 0.15
This is the first reported case of SJS associated with oxaprozin.
SJS Binding (associated) of associated with syndrome
12) Confidence 0.31 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9779863 Disease Relevance 0.52 Pain Relevance 0.18
Our literature review shows that among the NSAID associated with SJS, oxicams have the highest risk.
SJS Binding (associated) of associated with syndrome and cinod
13) Confidence 0.31 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9779863 Disease Relevance 0.54 Pain Relevance 0.20
SJS type I has recognized subtypes, IA and IB, which are similar except that type IB manifests earlier and with greater severity.
SJS Binding (recognized) of associated with syndrome
14) Confidence 0.29 Published 2008 Journal Cases J Section Body Doc Link PMC2533000 Disease Relevance 1.46 Pain Relevance 0
Peng et al. (1999) demonstrated that perlecan in vitro binds to acetylcholinesterase, and postulated that the perlecan-dystroglycan complex may function as an acceptor molecule for acetylcholinesterase at the neuromuscular junction. [9] Arikawa-Hirasawa et al. (2002) have shown that in perlecan-null mice, agrin and acetylcholine molecules were present at the neuromuscular junction but acetylcholinesterase was totally absent, indicating that perlecan binds acetylcholinesterase and localizes it at the synapse. [10]
perlecan Binding (binds) of in synapse
15) Confidence 0.27 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 0.39 Pain Relevance 0.05
A second strong association between HLA genotype and SJS/TEN has been reported for allopurinol.
SJS Binding (association) of associated with staphylococcus infection and bullous skin disease
16) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.56 Pain Relevance 0.53
Genetic susceptibility to SJS and TEN is likely as exemplified by the strong association observed in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and SJS induced by carbamazepine.
SJS Binding (susceptibility) of in leukocyte associated with staphylococcus infection, genetic predisposition to disease, bullous skin disease and carbamazepine
17) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC3018455 Disease Relevance 2.35 Pain Relevance 0.19
Subsequently, a strong association between SJS/TEN and HLA-B*5801 was found in Japanese patients [34], Thai patients [32], and also, to a lesser extent (55% of cases), in patients of European origin [36].


SJS Binding (association) of associated with staphylococcus infection and bullous skin disease
18) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.01 Pain Relevance 0.43
Drugs with reactive metabolites can modify cellular proteins and target an autoimmune response against the skin or liver cells.11 It now appears that the immunological mechanisms associated with SJS are initiated by the Fas antigen, a cell surface molecule that can mediate apoptosis.3
SJS Binding (associated) of in skin associated with syndrome and apoptosis
19) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846735 Disease Relevance 0.69 Pain Relevance 0.09
SJS has been associated with more than 100 drugs based on case reports and studies.4
SJS Binding (associated) of associated with syndrome
20) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846735 Disease Relevance 1.65 Pain Relevance 0.17

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