INT173120

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.79
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARA, NR1H4) nucleus (PPARA, NR1H4) lipid binding (PPARA)
signal transduction (NR1H4) small molecule metabolic process (PPARA) DNA binding (PPARA)
PPARA (Homo sapiens)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 93 99.84 Very High Very High Very High
Bile 9 82.16 Quite High
Inflammatory mediators 5 67.44 Quite High
cINOD 46 47.92 Quite Low
Inflammation 29 34.40 Quite Low
Inflammatory response 4 26.00 Quite Low
cytokine 29 5.00 Very Low Very Low Very Low
COX-2 inhibitor 20 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 194 99.72 Very High Very High Very High
Carcinoma 28 95.48 Very High Very High Very High
Disorder Of Lipid Metabolism 12 84.64 Quite High
Recurrence 4 81.00 Quite High
Liposarcoma 15 80.24 Quite High
Obesity 23 68.80 Quite High
INFLAMMATION 47 67.04 Quite High
Leukemia 10 66.68 Quite High
Skin Cancer 4 66.20 Quite High
Apoptosis 216 59.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since RXR forms a permissive heterodimeric complex with PPAR, and the activation
PPAR Binding (complex) of RXR
1) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.15 Pain Relevance 0.04
combination of RXR and PPAR?
PPAR Binding (combination) of RXR
2) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.10 Pain Relevance 0.08
These elements bind PPAR-RXR heterodimers with PPAR occupying the 5' extended half site and RXR the 3' half site [29].
PPAR Binding (bind) of RXR
3) Confidence 0.02 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.14 Pain Relevance 0
These elements bind PPAR-RXR heterodimers with PPAR occupying the 5' extended half site and RXR the 3' half site [29].
PPAR-RXR Binding (bind) of RXR
4) Confidence 0.02 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.14 Pain Relevance 0
Binding of PPAR:RXR to strong elements is reinforced when RXR?
PPAR Binding (Binding) of RXR
5) Confidence 0.02 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0 Pain Relevance 0.04
PPAR forms a heterodimeric complex with RXR and then recruits coactivator proteins.
PPAR Binding (complex) of RXR
6) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2841252 Disease Relevance 0 Pain Relevance 0
PPAR binds D3 to peroxisome proliferator response element (PPRE) as a heterodimer with the retinoic receptor (RXR) in the regulation of PPAR target genes (Figure 2).
PPAR Binding (binds) of RXR
7) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 0.14 Pain Relevance 0.03
PPAR binds D3 to peroxisome proliferator response element (PPRE) as a heterodimer with the retinoic receptor (RXR) in the regulation of PPAR target genes (Figure 2).
PPAR Binding (heterodimer) of RXR
8) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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