INT17313

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 57
Total Number 74
Disease Relevance 55.78
Pain Relevance 16.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HSPG2) small molecule metabolic process (HSPG2) extracellular region (HSPG2)
plasma membrane (HSPG2) extracellular matrix organization (HSPG2) lipid metabolic process (HSPG2)
Anatomy Link Frequency
skin 4
cranium 2
platelets 1
spinal 1
CHO 1
HSPG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 204 99.98 Very High Very High Very High
bradykinin 89 99.88 Very High Very High Very High
Kinase C 118 99.80 Very High Very High Very High
Opioid 17 99.80 Very High Very High Very High
chemokine 14 99.78 Very High Very High Very High
Spinal cord 65 99.68 Very High Very High Very High
Ventral tegmentum 4 99.68 Very High Very High Very High
cINOD 99 99.64 Very High Very High Very High
anticonvulsant 37 99.56 Very High Very High Very High
corticosteroid 115 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Staphylococcus Infection 2224 100.00 Very High Very High Very High
Bullous Skin Disease 1665 100.00 Very High Very High Very High
Syndrome 671 100.00 Very High Very High Very High
Disease 397 100.00 Very High Very High Very High
Infection 59 99.98 Very High Very High Very High
INFLAMMATION 156 99.50 Very High Very High Very High
Apoptosis 146 99.20 Very High Very High Very High
Li-fraumeni Syndrome 96 99.16 Very High Very High Very High
Natriuresis 1 99.16 Very High Very High Very High
Bacterial Respiratory Disease 37 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we mimicked the biological response of phospholipase C-gamma (PLC gamma) induction in the ventral tegmental area (VTA) observed after chronic morphine using viral-mediated gene transfer.
Positive_regulation (induction) of PLC in ventral associated with ventral tegmentum and morphine
1) Confidence 0.67 Published 2005 Journal Synapse Section Abstract Doc Link 15765533 Disease Relevance 0.10 Pain Relevance 0.51
Activation of phospholipase C (PLC) in response to stimulation of delta-opioid, m4 muscarinic and alpha2 adrenergic receptors was observed in NG108-15 cells.
Positive_regulation (Activation) of PLC in NG108-15 associated with opioid
2) Confidence 0.67 Published 1998 Journal Neuroreport Section Abstract Doc Link 9592056 Disease Relevance 0.05 Pain Relevance 0.32
Phospholipase A2 (PLA2), phosphatidylinositol-specific phospholipase C (PLC), and phospholipase D (PLD) are all activated by stretch.
Positive_regulation (activated) of PLC
3) Confidence 0.67 Published 1993 Journal J. Cell. Physiol. Section Abstract Doc Link 8468370 Disease Relevance 0 Pain Relevance 0.08
This case report presents evidence that SJS may be induced by radiation to other parts of the body in addition to the cranium while phenytoin is administered concomitantly.
Positive_regulation (induced) of SJS in cranium associated with syndrome
4) Confidence 0.59 Published 2010 Journal Radiat Oncol Section Abstract Doc Link 20525360 Disease Relevance 1.15 Pain Relevance 0.11
RESULTS: In the international case-control study, the oxicams were associated with the greatest increase in risk of SJS and TEN (relative risk 34, 95% confidence interval 11-105).
Positive_regulation (increase) of SJS
5) Confidence 0.59 Published 2003 Journal J. Rheumatol. Section Body Doc Link 14528522 Disease Relevance 0.33 Pain Relevance 0
Recently, following increased anatomical and biomechanical knowledge of the PLC’s key structures, various free graft surgical reconstruction techniques have been described [3, 9, 10, 21] that attempt functional restoration of the three key structures of the posterolateral corner (FCL, PFL, and PT).
Positive_regulation (increased) of PLC in corner
6) Confidence 0.50 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896579 Disease Relevance 0.64 Pain Relevance 0.05
PKC phosphorylation negatively modulates phospholipase C (PLC)beta, enzymes intimately associated with phosphoinositide turnover and calcium trafficking.
Positive_regulation (modulates) of PLC associated with kinase c
7) Confidence 0.49 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126111 Disease Relevance 0 Pain Relevance 1.77
Submicromolar rises in [Ca2+]i produced via activation of phospholipase C (PLC) or Ca2+ channel opening, provide a mechanism by which Ca2+/calmodulin (CaM) or protein kinase C (PKC)-sensitive isoforms of adenylyl cyclase can be regulated.
Positive_regulation (activation) of PLC associated with kinase c
8) Confidence 0.49 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.10
Inhibition of forskolin-stimulated adenylyl cyclase and phospholipase C beta (PLC beta) activation was measured in each of these cell lines.
Positive_regulation (activation) of PLC
9) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0 Pain Relevance 0.25
These data indicate that the expression of alpha-transducin scavenges free G(beta gamma) subunits and, furthermore, that free G(beta gamma) subunits play a role in opioid-mediated PLC beta activation and adenylyl cyclase superactivation, but not acute inhibition of forskolin-stimulated cAMP formation in hDOR/CHO cells.
Positive_regulation (activation) of PLC in CHO associated with opioid
10) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0.07 Pain Relevance 0.25
We have developed the coexpression system of both delta-opioid receptor (DOR1) and M2-muscarinic receptor (M2) which mediate agonist-evoked currents due to common post-receptor mechanisms including Gi1 and phospholipase C (PLC) activation in Xenopus oocytes reconstituted with Gi1 alpha.
Positive_regulation (activation) of PLC in oocytes associated with agonist and opioid receptor
11) Confidence 0.49 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472500 Disease Relevance 0 Pain Relevance 0.40
Aromatic antiepileptic drugs causing SJS/TEN in HLA-B*1502 carriers may act on a similar pathogenetic mechanism, although other genetic/nongenetic factor(s) may also contribute to the pathomechanism of the disease.
Positive_regulation (causing) of SJS
12) Confidence 0.45 Published 2010 Journal Pharmacogenomics Section Body Doc Link 20235791 Disease Relevance 0 Pain Relevance 0
Pretreatment of muscle cells with cANP-(4-23), a selective agonist of the natriuretic peptide clearance receptor, NPR-C, which activates phospholipase C (PLC)-beta3 via the betagamma-subunits of G(i-1) and G(i-2), inhibited the PLC-beta response to somatostatin and [D-Pen(2,5)]enkephalin.
Positive_regulation (activates) of PLC in muscle cells associated with natriuresis, somatostatin, agonist and enkephalin
13) Confidence 0.45 Published 2000 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11003572 Disease Relevance 0.10 Pain Relevance 0.59
The pathways by which the C-C chemokine receptors activate phospholipase C (PLC) were investigated in cotransfected COS-7 cells.
Positive_regulation (activate) of PLC associated with chemokine
14) Confidence 0.45 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8626727 Disease Relevance 0.18 Pain Relevance 0.23
Specifically, the FCL and PFL represent the main static stabilizers of the PLC, working as major restraints to primary varus and external rotation at lower angles of knee flexion (30°), whereas the popliteus muscle–tendon unit functions as the dynamic stabilizer of external rotation and posterior tibial translation at greater knee flexion angles [3–5].
Positive_regulation (stabilizers) of PLC in tendon
15) Confidence 0.44 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896579 Disease Relevance 0.27 Pain Relevance 0
Several AEDs have been associated with increased risk of developing SJS which include phenytoin, carbamazepine, lamotrigine and phenobarbital [7,8].
Positive_regulation (increased) of SJS associated with syndrome, lamotrigine and carbamazepine
16) Confidence 0.44 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2894848 Disease Relevance 1.70 Pain Relevance 0.32
When the risk for only recently initiated use was compared to that for longterm use of these agents (> 8 weeks), the relative risk of SJS and TEN associated with oxicams was significantly increased (p < 0.05).
Positive_regulation (increased) of SJS
17) Confidence 0.43 Published 2003 Journal J. Rheumatol. Section Body Doc Link 14528522 Disease Relevance 0.30 Pain Relevance 0
We report a case of doxycycline-induced SJS in a 46-year-old man.
Positive_regulation (induced) of SJS associated with syndrome
18) Confidence 0.41 Published 2007 Journal Cutis Section Abstract Doc Link 17388211 Disease Relevance 0.80 Pain Relevance 0.24
We report a 54-year-old man with SJS induced by carbamazepine.
Positive_regulation (induced) of SJS associated with syndrome and carbamazepine
19) Confidence 0.41 Published 2007 Journal Acta Pol Pharm Section Abstract Doc Link 17665856 Disease Relevance 1.15 Pain Relevance 0.21
Anticonvulsants that do not commonly cause SJS are metabolized differently.
Neg (not) Positive_regulation (cause) of SJS associated with syndrome and anticonvulsant
20) Confidence 0.40 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2894848 Disease Relevance 0.73 Pain Relevance 0.27

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