INT173159

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 96
Total Number 97
Disease Relevance 64.55
Pain Relevance 10.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
colon 2
adipose tissue 2
plasma 1
macrophages 1
stroma 1
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1771 100.00 Very High Very High Very High
COX2 94 100.00 Very High Very High Very High
Osteoarthritis 134 99.60 Very High Very High Very High
Inflammation 1220 99.28 Very High Very High Very High
Inflammatory response 140 99.12 Very High Very High Very High
Central nervous system 67 96.64 Very High Very High Very High
Bile 114 95.88 Very High Very High Very High
COX-2 inhibitor 52 93.44 High High
Thalamus 2 92.92 High High
cytokine 208 91.84 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 143 100.00 Very High Very High Very High
Pancreatic Cancer 26 100.00 Very High Very High Very High
Genetic Translocation 6 100.00 Very High Very High Very High
Apoptosis 1040 99.92 Very High Very High Very High
Colon Cancer 472 99.60 Very High Very High Very High
Diabetic Retinopathy 265 99.60 Very High Very High Very High
Osteoarthritis 136 99.60 Very High Very High Very High
Cancer 2849 99.56 Very High Very High Very High
Disorder Of Lipid Metabolism 203 99.46 Very High Very High Very High
Obesity 1484 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
show the importance of PPAR?
Localization (importance) of PPAR
1) Confidence 0.74 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.66 Pain Relevance 0
No

univocal changes were observed for PPAR?

Localization (observed) of PPAR
2) Confidence 0.74 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.92 Pain Relevance 0
Determination of PPAR?
Localization (Determination) of PPAR
3) Confidence 0.74 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.95 Pain Relevance 0.19
When the nuclear receptor is activated by a particular ligand binding to the ligand binding domain, this results in conformational changes to PPAR, and the receptor is released from binding with the corepressor.
Localization (released) of PPAR
4) Confidence 0.73 Published 2010 Journal PPAR Research Section Body Doc Link PMC2841252 Disease Relevance 0 Pain Relevance 0
In the past, the importance of PPAR?
Localization (importance) of PPAR
5) Confidence 0.73 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.08 Pain Relevance 0
is unclear as PPAR?
Localization (unclear) of PPAR
6) Confidence 0.73 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.11 Pain Relevance 0.34
in adipose tissue, suggesting that they are direct target of PPAR?
Localization (target) of PPAR in adipose tissue associated with obesity
7) Confidence 0.73 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.18 Pain Relevance 0.08
agonists raise plasma HDL levels, the physiological relevance of Lipg induction by PPAR?
Localization (relevance) of PPAR in plasma associated with agonist and disorder of lipid metabolism
8) Confidence 0.73 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.52 Pain Relevance 0.12
The ability of PPAR
Localization (ability) of PPAR
9) Confidence 0.73 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.59 Pain Relevance 0
In the presence of ligand, PPARs bind to their cognate regulatory
Localization (regulatory) of PPAR
10) Confidence 0.73 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 1.01 Pain Relevance 0.03
became clear that PPAR agonists cause a dramatic increase in
Localization (cause) of PPAR associated with agonist
11) Confidence 0.72 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 1.18 Pain Relevance 0.11
In this review, we focus on the functional role of PPARs and their cross-talk with other nuclear receptors in osteogenic differentiation and tumorigenesis and the potential use of PPAR?
Localization (use) of PPAR
12) Confidence 0.67 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.00 Pain Relevance 0.20
Transrepression occurs through sequestration of the coactivators CBP and SRC-1 by the PPAR/RXR heterodimers, preventing their utilization in other signaling pathways [62].
Localization (sequestration) of PPAR
13) Confidence 0.67 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.06 Pain Relevance 0
The regulation underlying these effects could be secondary to the nuclear competition between PPAR?
Localization (competition) of PPAR
14) Confidence 0.67 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.25 Pain Relevance 0.03
Colon cancer cell lines cultured in the presence of the PPAR?
Localization (presence) of PPAR in Colon associated with cancer
15) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 1.76 Pain Relevance 0
The chromosomal localization of the human and mouse PPAR genes
Localization (localization) of PPAR
16) Confidence 0.67 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.17 Pain Relevance 0.09
response to exposure to a wide range of PPAR?
Localization (range) of PPAR
17) Confidence 0.64 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.02 Pain Relevance 0.03
important, whereas the modification of PPAR?
Localization (modification) of PPAR
18) Confidence 0.64 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.07 Pain Relevance 0.04
ability of activated PPAR?
Localization (ability) of PPAR
19) Confidence 0.64 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.27 Pain Relevance 0.28
ligands, suggesting the use of PPAR?
Localization (use) of PPAR
20) Confidence 0.64 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.42 Pain Relevance 0.09

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