INT173166

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.01
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
colon 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 24 90.88 High High
Inflammation 34 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 47 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 4 100.00 Very High Very High Very High
Pancreatitis 44 99.00 Very High Very High Very High
Polyps 4 98.32 Very High Very High Very High
Colon Cancer 34 97.20 Very High Very High Very High
Multiple Organ Failure 33 89.52 High High
Sepsis 7 68.32 Quite High
Hepatocellular Cancer 16 66.24 Quite High
Apoptosis 97 50.00 Quite Low
Retinoblastoma 4 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggestion, however, does not exclude the possibility that significant PC deficiency could also be rate limiting for APC formation in patients with severe AP, as seems to be the case in septic children [17].
Negative_regulation (limiting) of APC Binding (formation) of associated with pancreatitis
1) Confidence 0.40 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.89 Pain Relevance 0
However, mice with preexisting damage to APC, a regulator of ?
Negative_regulation (preexisting) of APC Binding (damage) of
2) Confidence 0.15 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.10 Pain Relevance 0.07
On the other hand, two independent studies performed in mice bearing a mutation in the adenomatous polyposis coli tumor suppressor gene (APCmin) showed an increase in tumors or polyps in the colon after these mice were fed a diet containing a PPAR?
Negative_regulation (suppressor gene) of adenomatous polyposis coli Binding (mutation) of in colon associated with cancer, familial adenomatous polyposis and polyps
3) Confidence 0.15 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.02 Pain Relevance 0.12

General Comments

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