INT173169

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.81
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K1) cytoskeleton (MAP3K1) cytoplasm (MAP3K1)
Anatomy Link Frequency
cleavage 1
MAP3K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 91.72 High High
Inflammation 12 91.32 High High
adenocard 1 39.44 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 127 97.40 Very High Very High Very High
Stress 54 95.32 Very High Very High Very High
INFLAMMATION 14 91.32 High High
Shock 30 90.16 High High
Cancer 58 81.08 Quite High
Colon Cancer 17 76.28 Quite High
Liver Cancer 5 67.28 Quite High
Hepatocellular Cancer 8 35.52 Quite Low
Breast Cancer 3 26.64 Quite Low
Death 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CBD-tagged wild type MEKK1 or the C1238V mutant were expressed in cells, purified on chitin beads and then treated with PEITC in vitro.
Regulation (purified) of MEKK1
1) Confidence 0.41 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.20 Pain Relevance 0
MEKK1 is a large protein kinase [5] with activity that is regulated by multiple diverse means including phosphorylation and proteolytic cleavage [6-9].
Regulation (regulated) of MEKK1 in cleavage
2) Confidence 0.25 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.62 Pain Relevance 0.09
To determine whether inhibition of MEKK1 is due to direct modification of MEKK1 and not an effect on another member of the signaling pathway, we examined the sensitivity of purified MEKK1 to PEITC treatment in vitro.
Spec (whether) Regulation (modification) of MEKK1
3) Confidence 0.25 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.22 Pain Relevance 0
These results demonstrate that MEKK1 is directly modified and inhibited by ITCs, and that this correlates with inhibition of downstream activation of SAPK.
Regulation (modified) of MEKK1
4) Confidence 0.25 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2071920 Disease Relevance 0 Pain Relevance 0
We therefore tested the effects of nutritional ITCs on MEKK1, an upstream regulator of the SAPK/JNK signal transduction pathway.


Regulation (effects) of MEKK1
5) Confidence 0.25 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2071920 Disease Relevance 0.17 Pain Relevance 0
Both 3-phosphoinositide-dependent kinase-1 and integrin-linked kinase are target genes of PPAR?.
Regulation (target) of kinase-1
6) Confidence 0.00 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.60 Pain Relevance 0

General Comments

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