INT17317

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Context Info
Confidence 0.42
First Reported 1991
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.03
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Jun, Fos) nucleus (Jun, Fos) DNA binding (Jun, Fos)
transcription factor binding (Jun, Fos) cytosol (Jun) nucleolus (Fos)
Anatomy Link Frequency
SH-SY5Y 1
Jun (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 99.90 Very High Very High Very High
tolerance 5 99.78 Very High Very High Very High
Morphine 9 99.58 Very High Very High Very High
Pain 3 97.56 Very High Very High Very High
Endogenous opioid 2 93.44 High High
Spinal cord 3 92.64 High High
Opioid 7 91.92 High High
Dorsal horn 2 91.88 High High
Analgesic 1 90.32 High High
Dynorphin 24 90.04 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 99.52 Very High Very High Very High
Rheumatoid Arthritis 9 98.08 Very High Very High Very High
Stress 2 97.84 Very High Very High Very High
Pain 2 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-drug cues modulate morphine tolerance, striatal c-Fos, and AP-1 DNA binding.
AP-1 Binding (binding) of c-Fos associated with tolerance and morphine
1) Confidence 0.42 Published 1998 Journal Neuroreport Section Title Doc Link 9855286 Disease Relevance 0 Pain Relevance 1.08
Fos proteins are known to associate in transcriptional complexes with the products of the jun family constituting nuclear factor AP-1.
jun Binding (associate) of Fos
2) Confidence 0.29 Published 1991 Journal Oncogene Section Abstract Doc Link 1900356 Disease Relevance 0.37 Pain Relevance 0.38
Consistent with the notion that Fos and FRA proteins alter transcriptional activity by binding to AP-1 (or AP-1-like) DNA sequences in the promoter regions of target genes, we found that repeated APO treatment caused large increases in AP-1 binding activity in striata ipsilateral to 6-OHDA lesions.
AP-1 Binding (binding) of Fos
3) Confidence 0.29 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.62
Consistent with the notion that Fos and FRA proteins alter transcriptional activity by binding to AP-1 (or AP-1-like) DNA sequences in the promoter regions of target genes, we found that repeated APO treatment caused large increases in AP-1 binding activity in striata ipsilateral to 6-OHDA lesions.
AP-1 Binding (binding) of Fos
4) Confidence 0.29 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.62
Retinoic acid regulation of mu opioid receptor and c-fos mRNAs and AP-1 DNA binding in SH-SY5Y neuroblastoma cells.
AP-1 Binding (binding) of c-fos in SH-SY5Y associated with neuroblastoma and mu opioid receptor
5) Confidence 0.27 Published 2002 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11869806 Disease Relevance 0.66 Pain Relevance 0.42
The E(2)-induced increase in the level of Fos proteins and the binding of AP-1 proteins to DNA was inhibited by a single injection of ENK.
AP-1 Binding (binding) of Fos
6) Confidence 0.07 Published 2000 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 11074353 Disease Relevance 0 Pain Relevance 0.23
The level of estrogen- (ER) and progesterone receptor (PR) proteins, the hormone binding of E(2) receptors and the effects of single injection of ENK with or without naltrexone (NAL) on the E(2)-induced changes in the level of Fos and Jun proteins and the binding of AP-1 proteins to DNA were studied.
AP-1 Binding (binding) of Fos
7) Confidence 0.07 Published 2000 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 11074353 Disease Relevance 0 Pain Relevance 0.16

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