INT173177

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 12.61
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
adipose tissue 4
plasma 2
hepatocyte 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 365 100.00 Very High Very High Very High
Inflammation 257 99.28 Very High Very High Very High
COX-2 inhibitor 10 93.44 High High
antagonist 73 83.68 Quite High
Inflammatory response 33 82.16 Quite High
cytokine 27 73.44 Quite High
cINOD 49 72.24 Quite High
Taxol 1 54.16 Quite High
COX2 6 50.00 Quite Low
Glutamate 7 25.76 Quite Low
Disease Link Frequency Relevance Heat
Obesity 448 100.00 Very High Very High Very High
Pancreatic Cancer 14 100.00 Very High Very High Very High
Breast Cancer 58 99.98 Very High Very High Very High
Cancer 689 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 57 99.46 Very High Very High Very High
INFLAMMATION 313 99.28 Very High Very High Very High
Liver Cancer 16 98.32 Very High Very High Very High
Colon Cancer 125 96.84 Very High Very High Very High
Liposarcoma 28 96.56 Very High Very High Very High
Gastrointestinal Neoplasms 9 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
agonists raise plasma HDL levels, the physiological relevance of Lipg induction by PPAR?
Positive_regulation (induction) of Localization (relevance) of PPAR in plasma associated with agonist and disorder of lipid metabolism
1) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.52 Pain Relevance 0.12
in adipose tissue, suggesting that they are direct target of PPAR?
Positive_regulation (direct) of Localization (target) of PPAR in adipose tissue associated with obesity
2) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.18 Pain Relevance 0.08
became clear that PPAR agonists cause a dramatic increase in
Positive_regulation (increase) of Localization (cause) of PPAR associated with agonist
3) Confidence 0.48 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 1.19 Pain Relevance 0.11
response to exposure to a wide range of PPAR?
Positive_regulation (response) of Localization (range) of PPAR
4) Confidence 0.43 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.09 Pain Relevance 0.03
ability of activated PPAR?
Positive_regulation (activated) of Localization (ability) of PPAR
5) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.27 Pain Relevance 0.28
This finding suggests a potentially important use for PPAR?
Positive_regulation (important) of Localization (use) of PPAR
6) Confidence 0.42 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.27 Pain Relevance 0.06
Several PPAR target genes, such as CYP4A1, CPT1, or CD36, were induced in the two hepatocyte cultures treated by 40??
Positive_regulation (induced) of Localization (Several) of PPAR in hepatocyte
7) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.14 Pain Relevance 0
2 mRNA is increased in adipose tissue of obese men and women, and that the ratio of PPAR?
Positive_regulation (increased) of Localization (ratio) of PPAR in adipose tissue associated with obesity
8) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.46 Pain Relevance 0.07
The basis for the unique tissue specificity of Tusc5 expression remains unexplored, but the robust activation of Tusc5 gene expression by PPAR?
Positive_regulation (activation) of Localization (by) of PPAR
9) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.53 Pain Relevance 0.05
Nevertheless, some recent studies with the positive results on the possible application of PPAR?
Positive_regulation (results) of Localization (application) of PPAR
10) Confidence 0.36 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2770108 Disease Relevance 0.72 Pain Relevance 0.09
both COX-2-positive and COX-2-negative pancreatic tumors through PPAR-?
Positive_regulation (through) of Localization (pancreatic) of PPAR associated with pancreatic cancer
11) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.91 Pain Relevance 0.08
orientated to the clinical evaluation of PPAR-?
Positive_regulation (orientated) of Localization (evaluation) of PPAR
12) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.71 Pain Relevance 0
In an earlier study, Van Vlies and colleagues established a fasting-induced elevation of these genes that is PPAR?
Positive_regulation (induced) of Localization (elevation) of PPAR
13) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0 Pain Relevance 0
activation because two other PPAR?
Positive_regulation (activation) of Localization (because) of PPAR
14) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.84 Pain Relevance 0.15
lead to breakthrough in the clinical application of PPAR?
Positive_regulation (lead) of Localization (application) of PPAR
15) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.29 Pain Relevance 0.25
ligand-induced stabilization of PPAR?
Positive_regulation (induced) of Localization (stabilization) of PPAR
16) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0 Pain Relevance 0
This review focuses on the clinical use of PPAR?
Positive_regulation (focuses) of Localization (use) of PPAR
17) Confidence 0.19 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2605846 Disease Relevance 0.62 Pain Relevance 0
Nonetheless, additional clinical data demonstrate that short-term rosiglitazone therapy in patients with early-stage breast cancer leads to local and systemic effects on PPAR?
Positive_regulation (leads) of Localization (effects) of PPAR associated with breast cancer
18) Confidence 0.16 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.94 Pain Relevance 0.18
Interestingly, immediately afterwards, many of these sites become occupied by RXR and PPAR?
Positive_regulation (immediately) of Localization (occupied) of PPAR
19) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.15 Pain Relevance 0.06
Interestingly, immediately afterwards, many of these sites become occupied by RXR and PPAR?
Positive_regulation (by) of Localization (occupied) of PPAR
20) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.15 Pain Relevance 0.05

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