INT173180

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 3.66
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
gastrocnemius 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 209 99.84 Very High Very High Very High
Osteoarthritis 65 95.40 Very High Very High Very High
addiction 3 94.92 High High
Cannabinoid receptor 7 94.68 High High
Potency 7 92.40 High High
Spinal cord 2 89.72 High High
cytokine 35 88.76 High High
Endocannabinoid 35 88.76 High High
Inflammation 146 80.40 Quite High
cINOD 23 78.80 Quite High
Disease Link Frequency Relevance Heat
Obesity 217 97.84 Very High Very High Very High
Diabetes Mellitus 180 96.40 Very High Very High Very High
Osteoarthritis 66 95.40 Very High Very High Very High
Starvation 2 95.12 Very High Very High Very High
Fatty Liver 3 94.80 High High
Cancer 481 93.52 High High
Apoptosis 137 88.92 High High
INFLAMMATION 183 80.40 Quite High
Repression 18 79.60 Quite High
Multiple Myeloma 159 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
binding and PPARA transcriptional activation
Positive_regulation (activation) of PPARA Binding (binding) of
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
Thus, the G>A substitution decreases PPARA promoter affinity for the transcription factors ERR?
Positive_regulation (factors) of PPARA Binding (affinity) of
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
ligands do not necessarily require interaction with the PPAR?
Positive_regulation (require) of PPAR Binding (interaction) of
3) Confidence 0.46 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.27 Pain Relevance 0.21
membranes suggests that they could activate PPAR, induce PPAR binding to PPRE,
Positive_regulation (induce) of PPAR Binding (binding) of
4) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
These ligands induce PPAR binding to
Positive_regulation (induce) of PPAR Binding (binding) of
5) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
8/14 is a truncated receptor that results from aberrant splicing of the PPAR?
Positive_regulation (results) of PPAR Binding (splicing) of
6) Confidence 0.42 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.24 Pain Relevance 0
Whereas 15d-PGJ2 promotes direct binding of PPAR?
Positive_regulation (promotes) of PPAR Binding (binding) of
7) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.47 Pain Relevance 0.08
ligands usually occur at much higher concentrations than those required for ligand-dependent PPAR?
Positive_regulation (concentrations) of PPAR Binding (occur) of
8) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.42 Pain Relevance 0.19
(10 ng/ml) and stimulated, or not, with a synthetic ligand of PPAR?
Neg (not) Positive_regulation (stimulated) of PPAR Neg (not) Binding (ligand) of
9) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.17
Pdk4 was also induced in rat gastrocnemius muscle after treatment of the animals with the PPAR?
Positive_regulation (induced) of PPAR Binding (treatment) of in gastrocnemius
10) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.24 Pain Relevance 0.19
When treated with the PPAR?
Positive_regulation (When) of PPAR Binding (treated) of
11) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.12 Pain Relevance 0.12
1 mRNA levels were about 10-fold higher than PPAR?
Positive_regulation (fold) of PPAR Binding (higher) of
12) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906809 Disease Relevance 0.81 Pain Relevance 0.41
Therefore, the SAT of OBT2D subjects might be characterized by a relatively decreased activity of CB1 receptors, and strongly increased activity of PPAR?
Positive_regulation (increased) of PPAR Spec (might) Binding (activity) of associated with obesity
13) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 0.78 Pain Relevance 0.28
As mentioned above, the additional residues at N-terminus of PPAR?
Positive_regulation (mentioned) of PPAR Binding (terminus) of
14) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.07 Pain Relevance 0
Compound 24 also stimulated the binding of PPAR?
Positive_regulation (stimulated) of PPAR Binding (binding) of
15) Confidence 0.08 Published 2008 Journal Journal of Medicinal Chemistry Section Abstract Doc Link PMC2651753 Disease Relevance 0.17 Pain Relevance 0.24

General Comments

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