INT173198

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.58
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
colon 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 115 99.98 Very High Very High Very High
agonist 237 99.84 Very High Very High Very High
antagonist 63 99.84 Very High Very High Very High
Osteoarthritis 65 99.60 Very High Very High Very High
cINOD 43 81.96 Quite High
Arthritis 3 80.56 Quite High
Crohn's disease 1 75.60 Quite High
Bile 11 73.28 Quite High
chemokine 5 62.56 Quite High
cytokine 25 49.24 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 148 99.98 Very High Very High Very High
Osteoarthritis 66 99.60 Very High Very High Very High
Liposarcoma 12 99.24 Very High Very High Very High
Apoptosis 518 98.32 Very High Very High Very High
Inflammatory Bowel Disease 14 97.32 Very High Very High Very High
Cancer 516 97.04 Very High Very High Very High
Myeloid Leukemia 61 96.32 Very High Very High Very High
Colon Cancer 104 96.24 Very High Very High Very High
Malignant Neoplastic Disease 49 96.20 Very High Very High Very High
Targeted Disruption 35 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
antioxidant effects of the troglitazone, a synthetic ligand of PPAR?
Regulation (effects) of PPAR Binding (ligand) of
1) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.33 Pain Relevance 0.05
could illuminate yet another regulatory role for PPAR?
Regulation (regulatory) of PPAR Binding (role) of
2) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.33 Pain Relevance 0.06
Our laboratory has created and tested an engineered RXR/PPAR heterodimer consist of mouse RXR?
Regulation (tested) of PPAR Binding (heterodimer) of
3) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.07 Pain Relevance 0.03
Our laboratory has created and tested an engineered RXR/PPAR heterodimer consist of mouse RXR?
Regulation (/) of PPAR Binding (heterodimer) of
4) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.07 Pain Relevance 0.03
Synthetic and endogenous PPAR ligands have been used
Regulation (endogenous) of PPAR Binding (ligands) of
5) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.46 Pain Relevance 0
The

heterodimer PPAR/RXR can bind other transcriptional coactivators or

Regulation (heterodimer) of PPAR Binding (bind) of
6) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.63 Pain Relevance 0
-independent, as treatment with a PPAR?
Neg (independent) Regulation (independent) of PPAR Binding (treatment) of
7) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.20 Pain Relevance 0.05
As macrophages play important role in the anti-inflammatory effect in the colon, its correlation with PPAR?
Regulation (effect) of PPAR Binding (correlation) of in colon associated with inflammation
8) Confidence 0.33 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.70 Pain Relevance 0.38
to the range of its binding affinity for PPAR-?
Regulation (range) of PPAR Binding (affinity) of
9) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.71 Pain Relevance 0
Beneficial effects for the combined treatment with PPAR ligands plus
Regulation (effects) of PPAR Binding (ligands) of
10) Confidence 0.30 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.95 Pain Relevance 0.13
usage of the PPAR ligands with other agents may therefore be a critical strategy
Regulation (usage) of PPAR Binding (ligands) of
11) Confidence 0.30 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.64 Pain Relevance 0.07
Prolonged treatment with the PPAR?
Regulation (Prolonged) of PPAR Binding (treatment) of
12) Confidence 0.30 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.50 Pain Relevance 0
Thus, in the treatment with PPAR?
Regulation (Thus) of PPAR Binding (treatment) of
13) Confidence 0.28 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.63 Pain Relevance 0.05
To improve our understanding of the biology of PPAR?
Regulation (understanding) of PPAR Binding (biology) of
14) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.68 Pain Relevance 0.34
The PPAR DNA-binding activity is also modulated by the isotype of the RXR heterodimeric partner.
Regulation (modulated) of PPAR Binding (binding) of
15) Confidence 0.23 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0 Pain Relevance 0.04
This frameshift is a loss of function mutation that affects heterodimers formation and PPAR?
Regulation (affects) of PPAR Binding (formation) of
16) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.51 Pain Relevance 0
in different cell types, and how these may contribute to chromatin modifications and differential gene expression, represents a crucial issue for fulfilling our gap towards the understanding of PPAR?
Regulation (fulfilling) of PPAR Binding (understanding) of
17) Confidence 0.11 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0 Pain Relevance 0
Direct binding of compound 24 to PPAR?
Regulation (Direct) of PPAR Binding (binding) of
18) Confidence 0.06 Published 2008 Journal Journal of Medicinal Chemistry Section Abstract Doc Link PMC2651753 Disease Relevance 0.16 Pain Relevance 0.25

General Comments

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