INT173211

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.94
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MOCS1) small molecule metabolic process (MOCS1) nucleus (MOCS1)
MOCS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 95.52 Very High Very High Very High
tolerance 3 83.04 Quite High
agonist 2 80.52 Quite High
Angina 1 61.68 Quite High
antagonist 5 59.48 Quite High
cytokine 5 44.96 Quite Low
metalloproteinase 8 34.04 Quite Low
Potency 7 10.84 Low Low
Inflammatory response 1 10.48 Low Low
Tetrahydrobiopterin 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 1 99.98 Very High Very High Very High
Targeted Disruption 5 99.34 Very High Very High Very High
Diabetes Mellitus 46 98.52 Very High Very High Very High
INFLAMMATION 7 95.52 Very High Very High Very High
Hyperlipidemia 5 90.96 High High
Hypertension 6 90.16 High High
Insulin Resistance 12 89.60 High High
Staphylococcus Infection 27 78.88 Quite High
Prediabetic State 6 78.52 Quite High
Metabolic Syndrome 8 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of DMSO on enzyme activity is also important because it is commonly used as a solvent to dissolve compounds.
Regulation (effect) of enzyme
1) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0 Pain Relevance 0.04
Detailed biophysical analyses have demonstrated the strong stabilizing effect of these molecules on the enzyme.
Regulation (effect) of enzyme
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970562 Disease Relevance 0 Pain Relevance 0
In vivo, enzyme activity is highly regulated at a number of different levels (for example, gene expression and translation, proenzyme activation, enzyme-matrix interactions, endogenous inhibitors, and so on [17]).
Regulation (regulated) of enzyme
3) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.03
To have an effect on atheroscleropathy and T2DM it would not require a complete knockout of the gene but just one or two changes in the 1203 amino acid protein structure in the eNOS enzyme.
Neg (not) Regulation (changes) of enzyme associated with targeted disruption and diabetes mellitus
4) Confidence 0.00 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.46 Pain Relevance 0.10
Case drugs tend to bind to its peptidase active center and might interfere the suicide regulation [31] of the enzyme itself when the enzyme is over-expressed.
Spec (might) Regulation (regulation) of enzyme associated with suicidal behaviour
5) Confidence 0.00 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 0.48 Pain Relevance 0.05

General Comments

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