INT173212

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.22
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EPHB1) signal transduction (EPHB1) plasma membrane (EPHB1)
cytoplasm (EPHB1)
EPHB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 2 81.04 Quite High
Tetrahydrobiopterin 12 8.92 Low Low
agonist 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 7 95.84 Very High Very High Very High
Stress 19 92.68 High High
Impaired Glucose Tolerance 2 81.68 Quite High
Metabolic Syndrome 8 76.08 Quite High
Hypertension 5 71.60 Quite High
Hyperlipidemia 4 71.04 Quite High
Nicotine Addiction 2 70.04 Quite High
Diabetes Mellitus 46 63.64 Quite High
Cardiovascular Disease 5 51.32 Quite High
Increased Venous Pressure Under Development 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This endogenously produced competitive inhibitor of L-arginine (as well as an endogenous inhibitor of the eNOS reaction) would cause the eNOS reaction to uncouple and become a net producer of superoxide even before the glucose becomes elevated, thus stressing the islet and the intima before hyperglycemia is detected.
Positive_regulation (cause) of Gene_expression (producer) of net associated with hyperglycemia
1) Confidence 0.04 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.22 Pain Relevance 0.08

General Comments

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