INT173230

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Context Info
Confidence 0.13
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.32
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
thyroid 1
anterior pituitary 1
Sst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 176 95.52 Very High Very High Very High
cytokine 4 89.68 High High
agonist 12 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 98.72 Very High Very High Very High
Breast Cancer 4 86.40 High High
Leukemia 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, thyroid hormone triggers a specific induction of mRNA for sst1 and sst5 in murine thyrotropic tumors [32].
Positive_regulation (induction) of sst1 in thyroid associated with cancer
1) Confidence 0.13 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0.19 Pain Relevance 0.31
Demonstration of such an intra-testicular regulation would be reminiscent of the reported intra-hypothalamic "short loop negative feed-back" inhibition of GH secretion through GH-induced increase of sst1 receptor mRNA [38].



Positive_regulation (increase) of sst1
2) Confidence 0.09 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0.11
They are mediated via six receptors (sst1, sst2A, sst2B, sst3, sst4, sst5) encoded by five genes (sst1-5) located on distinct chromosomes.
Positive_regulation (mediated) of sst1
3) Confidence 0.09 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0.13
Interestingly, testosterone-induced up-regulation of sst1 receptor mRNAs has been reported in the rat anterior pituitary [36].
Positive_regulation (regulation) of sst1 in anterior pituitary
4) Confidence 0.09 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0.13 Pain Relevance 0.16

General Comments

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