INT173238

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sstr2) plasma membrane (Sstr2) cytoplasm (Sstr2)
signal transducer activity (Sstr2)
Sstr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 62 88.04 High High
dexamethasone 2 54.16 Quite High
agonist 12 51.64 Quite High
cytokine 1 44.00 Quite Low
Dopamine 2 13.24 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 8 92.76 High High
Breast Cancer 1 92.16 High High
Nelson Syndrome 3 90.88 High High
Acromegaly 4 87.48 High High
Cancer 18 86.36 High High
Adenoma 5 75.48 Quite High
Acth-secreting Pituitary Adenoma 7 70.80 Quite High
Pituitary Acth Hypersecretion 3 50.00 Quite Low
Cushing's Syndrome /

Hypercortisolism

30 5.00 Very Low Very Low Very Low
Recurrence 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation could be explained with the lack of glucocorticoid-induced down-regulation of sst2, as mentioned above.52
Negative_regulation (regulation) of sst2
1) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.50 Pain Relevance 0.13
Both positive and negative regulations of sst1 and sst2 receptors by glucocorticoids have been reported [35].
Negative_regulation (regulations) of sst2
2) Confidence 0.12 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0.18 Pain Relevance 0.21

General Comments

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