INT17325

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Context Info
Confidence 0.32
First Reported 1991
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.37

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peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
MVD 4
Plg (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 12 100.00 Very High Very High Very High
Antinociceptive 14 99.48 Very High Very High Very High
narcan 2 86.80 High High
Opioid 4 84.52 Quite High
Analgesic 6 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its antinociceptive activity, therefore, may be a consequence of both its PG synthetase inhibitory potency and another antinociceptive mechanism, the latter associated with its inhibitory potency in the MVD.
Negative_regulation (consequence) of Protein_catabolism (potency) of PG synthetase in MVD associated with antinociceptive and potency
1) Confidence 0.32 Published 1991 Journal J. Med. Chem. Section Abstract Doc Link 1900533 Disease Relevance 0 Pain Relevance 0.69
Its antinociceptive activity, therefore, may be a consequence of both its PG synthetase inhibitory potency and another antinociceptive mechanism, the latter associated with its inhibitory potency in the MVD.
Negative_regulation (inhibitory) of Protein_catabolism (potency) of PG synthetase in MVD associated with antinociceptive and potency
2) Confidence 0.32 Published 1991 Journal J. Med. Chem. Section Abstract Doc Link 1900533 Disease Relevance 0 Pain Relevance 0.68

General Comments

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