INT173272

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 13.85
Pain Relevance 11.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
neurons 2
liver 1
hepatocytes 1
muscle 1
brain 1
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 194 100.00 Very High Very High Very High
Hippocampus 167 100.00 Very High Very High Very High
Lasting pain 79 100.00 Very High Very High Very High
Spinal nerve ligature 58 100.00 Very High Very High Very High
amygdala 52 100.00 Very High Very High Very High
nMDA receptor 151 99.98 Very High Very High Very High
Nav1.2 352 99.76 Very High Very High Very High
Calcitonin gene-related peptide 13 98.88 Very High Very High Very High
B1 receptor 3 98.60 Very High Very High Very High
medulla 32 98.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 281 100.00 Very High Very High Very High
Nociception 130 99.60 Very High Very High Very High
Bordatella Infection 6 99.02 Very High Very High Very High
Overactive Bladder 4 98.96 Very High Very High Very High
Diabetes Mellitus 253 98.74 Very High Very High Very High
Stress 342 98.48 Very High Very High Very High
Obesity 60 98.34 Very High Very High Very High
Spinal Cord Injury 8 94.64 High High
INFLAMMATION 552 93.88 High High
Sepsis 235 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin-induced responses (Fig. 2)
Phosphorylation (responses) of Fig
1) Confidence 0.48 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151796 Disease Relevance 0.08 Pain Relevance 0.04
We were also able to localize phosphorylated downstream targets of mTOR (Fig. 2A) co-existing with PGP, CGRP and N52 such as phospho-4E-BP1/2, phospho-S6K and phospho-S6 protein in skin tissue, (Fig. 2D-F and Fig. 3B).
Phosphorylation (phosphorylated) of Fig in skin associated with calcitonin gene-related peptide
2) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.44
0.092) towards reduced phosphorylation of AKT residue Ser473 was detected (Fig. 4B). 24 h LPS infusion had no effect on the protein level or phosphorylation state of residues Thr421 and Ser424 of p70 S6K (Fig. 4C & 4D), nor on the phosphorylation state of Thr37 and Thr46 of 4E-BP1 (Fig. 4E), where both p70 S6K and 4E-BP1 are located downstream of AKT.
Phosphorylation (phosphorylation) of Fig
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.03
0.092) towards reduced phosphorylation of AKT residue Ser473 was detected (Fig. 4B). 24 h LPS infusion had no effect on the protein level or phosphorylation state of residues Thr421 and Ser424 of p70 S6K (Fig. 4C & 4D), nor on the phosphorylation state of Thr37 and Thr46 of 4E-BP1 (Fig. 4E), where both p70 S6K and 4E-BP1 are located downstream of AKT.
Phosphorylation (phosphorylation) of Fig
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.03
In contrast, injection of CFA into the cutaneous site only produced an increase in NMDA receptor phosphorylation (Fig. 8A right) and GFAP (Fig. 8B right) levels in the Vc without an effect in Vi/Vc.


Phosphorylation (phosphorylation) of Fig associated with nmda receptor
5) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.09 Pain Relevance 0.84
As shown in Fig. 8, injection of CFA into the masseter produced significant increases in NR1 serine 896 phosphorylation (Fig. 8A left) and GFAP levels (Fig. 8B left) in both Vi/Vc and caudal Vc.
Phosphorylation (phosphorylation) of Fig in masseter
6) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.99 Pain Relevance 0.79
In contrast, injection of CFA into the cutaneous site only produced an increase in NMDA receptor phosphorylation (Fig. 8A right) and GFAP (Fig. 8B right) levels in the Vc without an effect in Vi/Vc.


Phosphorylation (phosphorylation) of Fig associated with nmda receptor
7) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.08 Pain Relevance 0.84
Fig. 4 A showed reduced and increased tyrosine phosphorylation of nuclear and cytoplasmic Grb7, respectively, at 30 min and 90 min of EGF treatment.
Phosphorylation (phosphorylation) of Fig
8) Confidence 0.22 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.06 Pain Relevance 0.03
0.028) mitochondria state III respiration (the ability to phosphorylate ADP into ATP), which was efficiently prevented by treatment of L-NIL (Fig. 6A,B).
Phosphorylation (phosphorylate) of Fig
9) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2674956 Disease Relevance 0.09 Pain Relevance 0.11
JNK phosphorylation in liver, muscle and adipose tissue were increased in septic animals and atorvastatin induced a downmodulation in the phosphorylation of this serine kinase (Fig. 4A–C).
Phosphorylation (phosphorylation) of Fig in liver associated with obesity
10) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.69 Pain Relevance 0.04
In primary hepatocytes, insulin, TCA, and DCA induced an increase in FOX01 phosphorylation on thr24 (Fig. 4).
Phosphorylation (phosphorylation) of Fig in hepatocytes
11) Confidence 0.20 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.08 Pain Relevance 0.04
At each time point showing enhanced phosphorylation of ERKs by pain stimulation, no significant differences were found between the transient pain and the persistent pain group (Fig. 3).
Phosphorylation (phosphorylation) of Fig associated with pain and lasting pain
12) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.49
Some of the most pronouncedly affected pathways were involved in oxidative phosphorylation (26 genes, of which 19 down-regulated; Fig.
Phosphorylation (phosphorylation) of Fig
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.17 Pain Relevance 0.11
Both BRL-44408 (1 µM) and pertussis toxin (PTX, 100 ng/ml) prevented the NE-induced phosphorylation of the p38 MAP kinase (Fig. 6A).
Phosphorylation (phosphorylation) of Fig associated with bordatella infection
14) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 0.34 Pain Relevance 0.08
Our results showed that insulin combined with GJG treatment significantly increases the amount of the IRS-1 protein (Fig. 5A) and inhibits its increased tyrosine phosphorylation level more than insulin alone.
Phosphorylation (phosphorylation) of Fig
15) Confidence 0.16 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.47 Pain Relevance 0
Surprisingly, phosphorylation of the substrate(s) of activated MEK1/2, Erk1/2, was increased to a much smaller extent, and in some brain regions (hippocampus, amygdala) not at all (Fig. 1, bottom).
Phosphorylation (phosphorylation) of Fig in brain associated with hippocampus and amygdala
16) Confidence 0.13 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.60 Pain Relevance 0.33
The present data revealed that insulin + GJG treatment inhibits the increased IRS-1 tyrosine phosphorylation levels (Fig. 5B); therefore, these improvements are thought to improve the abnormal activation of PI 3-kinase (8,9) resulting in the correction of decreased efficiency of glucose metabolization.
Phosphorylation (phosphorylation) of Fig
17) Confidence 0.13 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.30 Pain Relevance 0
Compared to that of Sham-Saline group, the level of anti-phosphorylated NR1 (pNR1) was significantly increased in SNL-Saline group on POD 7 (P < 0.05 compared to Sham-Saline) (Fig 2).
Phosphorylation (phosphorylated) of Fig associated with spinal nerve ligature
18) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.21 Pain Relevance 1.11
Administration of PP2, which inhibits the Src family of protein tyrosine kinases, prior to administration of ephrinB2, prevented the increase in NR2B tyrosine phosphorylation (Fig. 1A lane 3 vs. lane 1 and 2).
Phosphorylation (phosphorylation) of Fig
19) Confidence 0.12 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.12 Pain Relevance 0.21
In both cases, intrathecal injection of PD98059 strongly reduced the frequency [24, 26] and amplitude of bladder contractions [26] (Fig. 6), indicating that spinal ERK phosphorylation is important to regulate micturition in pathological conditions.
Phosphorylation (phosphorylation) of Fig in spinal associated with overactive bladder and intrathecal
20) Confidence 0.12 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.87 Pain Relevance 0.51

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