INT17332

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.78
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
dentate gyrus 2
neurons 2
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 18 100.00 Very High Very High Very High
Neurotransmitter 98 98.48 Very High Very High Very High
Ventral tegmentum 1 95.20 Very High Very High Very High
Pain 5 93.68 High High
antagonist 12 92.76 High High
Dopamine 2 91.80 High High
Glutamate 22 84.72 Quite High
Spinal cord 1 57.60 Quite High
tetrodotoxin 1 56.72 Quite High
tolerance 1 50.60 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 5 100.00 Very High Very High Very High
Neuroblastoma 1 99.26 Very High Very High Very High
Pain 4 93.68 High High
Stress 2 74.48 Quite High
Disease 7 55.04 Quite High
Cancer 5 51.20 Quite High
Lymphatic System Cancer 1 38.40 Quite Low
Chronic Disease 1 38.40 Quite Low
Hypertension 9 36.40 Quite Low
Diabetes Mellitus 2 35.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection experiments in NCB20 neuroblastoma cells indicated that this site is a target of Fos/Jun trans-activation.
Regulation (target) of Positive_regulation (trans-activation) of Fos associated with neuroblastoma
1) Confidence 0.44 Published 1991 Journal Neuron Section Abstract Doc Link 1901718 Disease Relevance 0.32 Pain Relevance 0.24
The increased levels of proenkephalin mRNA in the dentate gyrus following hippocampal stimulation have been assumed to be a consequence of the transient induction of c-fos.
Regulation (consequence) of Positive_regulation (induction) of c-fos in dentate gyrus
2) Confidence 0.44 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7984041 Disease Relevance 0 Pain Relevance 0
In order to determine whether neurotransmitter expression is modulated in response to the elevation of neurotrophins, the changes in c-fos, neuropeptide and glutamic acid decarboxylase (GAD) mRNAs expression was evaluated after BDNF or NT-3 was applied to cultured spinal neurons.
Regulation (changes) of Positive_regulation (evaluated) of c-fos in neurons associated with neurotransmitter, generalized anxiety disorder and neuropeptide
3) Confidence 0.44 Published 2000 Journal Neuroreport Section Abstract Doc Link 11117506 Disease Relevance 0.35 Pain Relevance 0.33
Appetitive odor-conditioning for c-fos stimulation
Regulation (conditioning) of Positive_regulation (stimulation) of c-fos
4) Confidence 0.44 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2914567 Disease Relevance 0 Pain Relevance 0
It has been hypothesized that blockade of D2 receptors by antipsychotics is responsible for the induction of c-fos, but the mechanism has not been determined.
Regulation (responsible) of Positive_regulation (induction) of fos
5) Confidence 0.17 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12695877 Disease Relevance 0 Pain Relevance 0.31
It is now known that light entrainment of the clock involves the induction of c-Fos [274] and clock genes per1 and per2 [275-277].
Regulation (involves) of Positive_regulation (induction) of Fos
6) Confidence 0.04 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.11 Pain Relevance 0.24

General Comments

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