INT17333

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 6.06
Pain Relevance 8.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
TNC 6
sensory neurons 2
dentate gyrus 2
brain 2
cingulate cortex 2
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 50 100.00 Very High Very High Very High
qutenza 15 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
nMDA receptor 11 99.78 Very High Very High Very High
Opioid 8 99.74 Very High Very High Very High
nociceptor 6 99.50 Very High Very High Very High
Analgesic 4 99.50 Very High Very High Very High
medulla 9 99.40 Very High Very High Very High
metalloproteinase 73 98.86 Very High Very High Very High
tolerance 6 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 59 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 99.76 Very High Very High Very High
Shock 2 99.38 Very High Very High Very High
Hypoxia 13 96.44 Very High Very High Very High
Pain 9 96.16 Very High Very High Very High
Nociception 6 94.12 High High
Headache 8 94.00 High High
Sprains And Strains 4 93.72 High High
Stress 111 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all brain regions analysed, exposure to CRD induced an increase in c-Fos activation in both the WKY and SD rats.
Positive_regulation (increase) of Positive_regulation (activation) of c-Fos in brain
1) Confidence 0.67 Published 2010 Journal Neuroscience Section Abstract Doc Link 19765638 Disease Relevance 0.76 Pain Relevance 0.77
By double-labeling in situ hybridization/immunohistochemistry, we show that increased prodynorphin gene expression is preceded, in the same neurons, by an early induction of c-fos.
Positive_regulation (preceded) of Positive_regulation (induction) of c-fos in neurons
2) Confidence 0.49 Published 1991 Journal Neuron Section Abstract Doc Link 1901718 Disease Relevance 0.33 Pain Relevance 0.22
This “upward” shift in sensitized animals, visible in the histogram of optical density frequencies, indicates that the increase in c-fos positive nuclei is not due to nuclei that were under our detection threshold for c-fos increasing their reactivity enough to be measured.
Neg (not) Positive_regulation (due) of Positive_regulation (increase) of c-fos
3) Confidence 0.49 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.26
After the i.p. injection of kynurenine combined with probenecid it was found that the stimulation-induced increase in the c-fos immunoreactivity of the secondary sensory neurons does not occur.
Positive_regulation (stimulation-induced) of Positive_regulation (increase) of c-fos in sensory neurons
4) Confidence 0.49 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17382471 Disease Relevance 0.26 Pain Relevance 0.33
Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid.
Positive_regulation (stimulation-induced) of Positive_regulation (increase) of c-fos in nucleus associated with analgesic
5) Confidence 0.49 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17382471 Disease Relevance 0.40 Pain Relevance 0.91
Activation of NMDA receptors will also lead to activation of the early gene transcription factors including AP-1 (c-fos, c-jun) and NF-kappaB which may play a role in modulation of the subsequent response to hypoxia.
Positive_regulation (lead) of Positive_regulation (activation) of c-fos associated with hypoxia and nmda receptor
6) Confidence 0.49 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15950554 Disease Relevance 0.33 Pain Relevance 0.70
GTN infusion (2 microg/kg/min for 30 min) did not lead to enhanced c-fos LI after 2 h and 4 h, whereas capsaicin infusion caused a time- and dose-dependent expression of c-fos LI within laminae I and II of the TNC.
Neg (not) Positive_regulation (lead) of Positive_regulation (enhanced) of c-fos in TNC associated with qutenza
7) Confidence 0.49 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.15 Pain Relevance 0.74
This is most likely due to a feedback inhibition of nitric oxide synthases, which indicates that the c-fos response to capsaicin within TNC is mediated by NO dependent mechanisms.
Neg (NO) Positive_regulation (mediated) of Positive_regulation (response) of c-fos in TNC associated with qutenza
8) Confidence 0.49 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.14 Pain Relevance 0.75
Administration of RTX blocked both inflammation-induced hyperalgesia and spinal c-Fos induction.
Positive_regulation (inflammation-induced) of Positive_regulation (induction) of c-Fos in spinal associated with hyperalgesia and inflammation
9) Confidence 0.49 Published 2003 Journal Pain Section Abstract Doc Link 12855332 Disease Relevance 0.90 Pain Relevance 0.82
The expression levels of heat shock protein 70 (HSP70), c-jun and c-fos genes were remarkably up-regulated and those of c-myc and poly (ADP ribose) polymerase (PARP) were down-regulated in bupivacaine-treated cells.
Positive_regulation (up-regulated) of Positive_regulation (up-regulated) of c-fos in poly associated with shock
10) Confidence 0.49 Published 2003 Journal J Toxicol Sci Section Abstract Doc Link 12820540 Disease Relevance 0.68 Pain Relevance 0.05
Other neuroadaptations resulting from chronic opioid use include upregulation of the cAMP pathway, an increase in the cAMP response element-binding protein and Fos-related antigens.
Positive_regulation (upregulation) of Positive_regulation (increase) of Fos associated with opioid
11) Confidence 0.49 Published 2001 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11207668 Disease Relevance 0.08 Pain Relevance 0.85
Rimcazole inhibited PCP c-fos induction in the cingulate and parietal cortices and DTG c-fos induction in the cingulate cortex.
Positive_regulation (induction) of Positive_regulation (induction) of c-fos in cingulate cortex
12) Confidence 0.49 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.07 Pain Relevance 0.48
In contrast, there is a widespread induction of c-fos mRNA throughout the dentate gyrus, 45 min after injection of either vehicle or NMDA, suggesting that induction of c-fos expression is unrelated to the subsequent, anatomically discrete, increase in proenkephalin mRNA levels.
Positive_regulation (is) of Positive_regulation (induction) of c-fos in dentate gyrus
13) Confidence 0.49 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7984041 Disease Relevance 0 Pain Relevance 0
Meal-elicited gastrointestinal stimuli activate distinct patterns of c-fos neural activation within caudal brainstem sites, where gut vagal afferents terminate.
Positive_regulation (activate) of Positive_regulation (activation) of c-fos in brainstem associated with medulla
14) Confidence 0.45 Published 2000 Journal Nutrition Section Abstract Doc Link 11054591 Disease Relevance 0 Pain Relevance 0.28
In fibroblasts, the cell-permeable ceramide analogue C2-ceramide has been shown to stimulate mRNA expression for MMP-1 and MMP-3 through activation of signal pathways that ultimately lead to the induction of c-jun and c-fos and AP-1-dependent transcription of MMP genes [10].
Positive_regulation (lead) of Positive_regulation (induction) of c-fos in fibroblasts associated with metalloproteinase
15) Confidence 0.45 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400415 Disease Relevance 0.71 Pain Relevance 0.43
Activation of AP-1 occurs in the presence of low levels of ROS (mainly H2O2), IL-1, UV light, and ?
Positive_regulation (occurs) of Positive_regulation (Activation) of AP-1
16) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.16 Pain Relevance 0.11
Activation of NMDA receptors will also lead to activation of the early gene transcription factors including AP-1 (c-fos, c-jun) and NF-kappaB which may play a role in modulation of the subsequent response to hypoxia.
Positive_regulation (lead) of Positive_regulation (activation) of AP-1 associated with hypoxia and nmda receptor
17) Confidence 0.01 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15950554 Disease Relevance 0.33 Pain Relevance 0.70

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