INT173338

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.52
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
Anatomy Link Frequency
smooth muscle 10
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 165 99.98 Very High Very High Very High
cytokine 24 94.32 High High
Inflammation 135 77.72 Quite High
bradykinin 22 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
c fibre 8 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 16 88.52 High High
Disease 62 78.32 Quite High
INFLAMMATION 156 77.72 Quite High
Pulmonary Disease 204 75.36 Quite High
Asthma 199 60.48 Quite High
Occupational Lung Diseases 21 27.44 Quite Low
Airway Remodeling 70 5.00 Very Low Very Low Very Low
Hypertrophy 24 5.00 Very Low Very Low Very Low
Hyperplasia 16 5.00 Very Low Very Low Very Low
Viral Infection 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with these observations, cholinergic agonist-induced RhoA translocation to the membrane, RhoA-mediated Ca2+ sensitization, and contraction are increased in bronchial smooth muscle from rats and mice exposed to repeated allergen challenge [45,48,49].
Positive_regulation (induced) of Localization (translocation) of RhoA in smooth muscle associated with agonist
1) Confidence 0.14 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.31 Pain Relevance 0.17
In line with these observations, cholinergic agonist-induced RhoA translocation to the membrane, RhoA-mediated Ca2+ sensitization, and contraction are increased in bronchial smooth muscle from rats and mice exposed to repeated allergen challenge [45,48,49].
Positive_regulation (increased) of Localization (translocation) of RhoA in smooth muscle associated with agonist
2) Confidence 0.14 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.32 Pain Relevance 0.17
RhoA protein levels are increased, and acetylcholine-induced translocation of RhoA to the plasma membrane is significantly higher in bronchial smooth muscle from airway hyperresponsive versus control rats [70,198].
Positive_regulation (induced) of Localization (translocation) of RhoA in smooth muscle
3) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.25 Pain Relevance 0.07
In line with these observations, cholinergic agonist-induced RhoA translocation to the membrane, RhoA-mediated Ca2+ sensitization, and contraction are increased in bronchial smooth muscle from rats and mice exposed to repeated allergen challenge [45,48,49].
Positive_regulation (increased) of Localization (translocation) of RhoA in smooth muscle associated with agonist
4) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.32 Pain Relevance 0.17
In line with these observations, cholinergic agonist-induced RhoA translocation to the membrane, RhoA-mediated Ca2+ sensitization, and contraction are increased in bronchial smooth muscle from rats and mice exposed to repeated allergen challenge [45,48,49].
Positive_regulation (induced) of Localization (translocation) of RhoA in smooth muscle associated with agonist
5) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.32 Pain Relevance 0.17

General Comments

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