INT173356

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (CDK20) GTPase activity (Gnaq) protein complex (Gnaq)
cytoplasm (CDK20) signal transducer activity (Gnaq) cytosol (Gnaq)
Gnaq (Mus musculus)
CDK20 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 36 100.00 Very High Very High Very High
bradykinin 20 93.80 High High
agonist 114 83.88 Quite High
adenocard 16 60.80 Quite High
Inflammation 22 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 86 31.76 Quite Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 18 5.00 Very Low Very Low Very Low
Bronchospasm 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Airway Remodeling 4 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects appear in part Gq-dependent (Billington and Penn, unpublished observations) and may be mediated by the capacity of Gq signaling to stimulate the p42/p44 MAPK (via PKC-mediated phosphorylation of Raf-1) and p70S6K pathways and therefore induce promitogenic transcription factor activation, cyclin D1 induction, and upregulate the translational machinery necessary for cell cycle progression [36,37].
Gq Positive_regulation (stimulate) of p42 associated with kinase c
1) Confidence 0.06 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.15
Gq-dependent activation of PKC and p42/p44 also promotes phosphorylation and activation of phospholipase A2 (PLA2), which contributes to rapid eicosanoid synthesis in ASM cells stimulated with bradykinin (acting on B2 bradykinin receptors)[39].
Gq Positive_regulation (activation) of p42 associated with kinase c and bradykinin
2) Confidence 0.06 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.22

General Comments

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